Quinine pharmacokinetics and toxicity
this drug is absorbed well from the GI tract, metabolized by hydroxylation, and then renally excreted. It has a short half-life, thus given 3x per day. Toxicity: cinchonism (tinnitus, headache, nausea, dizziness, flushing, blurred vision). Other side effects: cardiac depressant, resp rate changes, stimulates uterine contractions, may stimulate insulin release (hypoglycemia), and hemolytic anemia (exp with G6PD deficiency).