Only $35.99/year

Bauman/Students Environmental and Nutritional Disorders

Terms in this set (13)

-It acts to stimulate release of dopamine in the CNS, thereby increasing dopamine levels
-Dopamine is a class of neurotransmitter that is involved in a wide range of behaviours (movement in Parkinsons, emotions such as reward, motivation, pleasure)
-Dopamine pathways include the ventral tegmental area (VTA), striatum, nucleus accumbens, and frontal cortex
-The dopamine transporter (DAT) regulates dopaminergic transmission by facilitating dopamine reuptake.
-Amphetamines act in two ways:
o By blocking dopamine reuptake via binding to DAT and preventing transportation out of synaptic cleft
o It also reverses the direction of DA transport through the channel, leading to increased DA release.
-Human data overwhelmingly implicate meth abuse in the development of characteristic neurocognitive impairments that are both dose- and duration-dependent in severity.
-Single doses of amphetamine have been shown to improve performance in several domains of neurocognitive functioning in normal humans
-Meth abusers appear to develop different cognitive impairments than do abusers of other stimulants or other classes of illicit drugs (e.g. cocaine and heroin)
o Meth abusers demonstrate impaired performance on tasks that combine attention and visuomotor scanning (Trail making test: connecting points that are scattered)
o Abusers of meth or amphetamine also demonstrate deficits on tests such as the Stroop test for attentional control and executive function (identify ink color)
-As opposed to mood disturbance (e.g. depression) that spontaneously resolves within three weeks after abstinence, impairment of cognitive functioning in meth-dependent patients persists well into abstinence (cognitive impairment persists even after 8+ months post-abstinence)
-Currently there are no medications (e.g. antidepressants like SSRIs) that can treat the mood disturbances (e.g. depression and dysphoria) associated with chronic methamphetamine use