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Dr. Bansal - February 3, 2012 Semester 4, Mini 1
Terms in this set (23)
What endogenous compounds, other than T3&4, act to inhibit the pituitary release of TSH?
corticoids, dopamine, somatostatin
What is the tx for Hashimoto's disease?
What is the condition associated with congenital hypothyroidism?
What is the treatment?
Pt presents unconscious, in respiratory depression, hypothermia, dry, rough skin and a history of hypothyroidism. What is the treatment?
What is the hormone replacement for T3?
What about T4
What is the treatment plan for an endemic goiter?
low does potassium iodide
if severe: levothyroxine
When is a fetus dependent on the mother for thyroxine? How must the therapy of a pregnant hypothyroid pt change?
→ ↑ dose 30-50%
What drug have a high chance of causing drug induced hypothyroidism?
radioactive iodine 131-I
What are the 3 main treatment options to deal with hyperthyroidism?
What thioamide is preferred in pregnancy?
What thioamide has an extra MOA that makes it useful in the tx of a thyroid storm?
What are tx options for Graves disease?
What is their common MOA of thioamides - propylthiouracil?
inhibit thyroid peroxidase
→ blocking organification of iodine
What accounts for the long onset of thioamides - propylthiouracil?
they do not affect the already stored colloid hormones
What is a serious adverse effect of thioamides - propylthiouracil?
What is the Black Box warning associated with propyluracil?
severe liver damage leading to acute failure
What orally administer drug obliterates the thyroid and is used to tx severe graves disease and functional thyroid carcinomas?
When is the use of I-131 contraindicated?
pregnancy or lactation
What drugs are Iodide salts?
KI and Lugol Solution (I+KI; 2:1)
How do iodide salts work treat hyperthyroidism?
1. Inhibit hormone release
2. Inhibit organification
3. Reduce vascularity to a hyperplastic gland
When would the mechanism of iodide salts to reduce the vascularity to a hyperplastic gland be most useful?
Following radioactive fallout, what is given to patients to protect their thyroids from 131-I exposure?
What is the drug of choice in a thyroid storm? What else is used to control cardiovascular symptoms if these are contraindicated?
esmolol (or propanolol)
if β-blockers are c/i: CCBs
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