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Terms in this set (41)
What are claudins?
family of proteins that are the most important components of the tight junctions
allow for movement of select molecules between cells
tightly bind cells together
The apical surface is...
the surface facing out towards a cavity
The basal surface is...
the surface facing towards the ECM
ECM stands for...
Adherens junction is connected to...
Desmosomes connect to...
What is the difference between desmosomes and hemidesmosomes?
Desmosomes connect on the sides of epithelial cells while hemidesmosomes anchor the cells to the basal lamina
What does CAM stand for?
cell adhesion molecule
What are the main types of CAMs?
Homotypic adhesion means...
adhesive interactions between cells of the same type
Heterotypic adhesion means...
a CAM on one cell binds to a different CAM on adjacent cell
Type-1 Transmembrane Protein
homophilic velcro adhesion
Ig Superfamily has what type of adhesion?
homophilic and heterophilic
Act as receptors or CAMs binding to larger protein complexes
contain carbohydrate-binding domain
Types of ECM Proteins
Multi-adhesive Matrix proteins
Component of Proteoglycan
Types of Multi-adhesive Matrix proteins in ECM
What role does ECM play?
Regulatory role in determining shape and activities of the cell
What degrades the ECM?
matrix metalloproteinases (MMPs)
What do fibroblast cells do?
Main types of epithelial cells
elongated cells including mucus-secreting cells and absorptive cells
line the blood vessels and body cavity
Several layers of cells with different shapes, line certain cavities subject to expansion and contraction
Line surfaces at mouth and esophagus
Linings resist abrasion and generally do not participate in absorption and secretion
What are the three main categories of junctions?
control the flow of solute through extracellular spaces between cells
anchoring junctions that connect lateral membranes of adjacent epithelial cells
snap-like points of contact between epithelial and some other types of cells such as smooth muscle
found mainly on the basal surface of epithelial cells
allow movement of small molecules and ions between the cytosols of adjacent cells
line of mouse fibroblast cells
What is needed for fibroblast cells to aggregate into sheets?
E-cadherin gene and Ca2+
Madin-Darby canine kidney
What are some adaptor proteins for E-cadherins?
Catenins, ZO1, Actinin, VASP, vinculin
transcription factor that suppresses the expression of E-cadherin
What cadherins make up desmosomes?
Desmoglein and Desmocollin
What adaptor proteins are bonding to desmosomes?
Plakoglobin, Desmoplakins, and Plakophilins
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