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Science
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Rheumatology
First Aid - Autoantibodies
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Antinuclear antibodies (ANA)
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Lupus (97% sensitive),
drug-induced lupus,
RA,
Juvenile arthritis
polymyositis,
dermatomyositis
Sjogren's
Scleroderma,
type 1 autoimmune hepatitis,
mixed connective tissue disorders
-pos in 10% of nl people ***a ton of autoimmune disorders
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Terms in this set (37)
Antinuclear antibodies (ANA)
Lupus (97% sensitive),
drug-induced lupus,
RA,
Juvenile arthritis
polymyositis,
dermatomyositis
Sjogren's
Scleroderma,
type 1 autoimmune hepatitis,
mixed connective tissue disorders
-pos in 10% of nl people ***a ton of autoimmune disorders
Anti-dsDNA
Lupus (only seen in 60%)
-can indicate
renal
involvement and be helpful to monitor progression of disease
anti-Smith
very specific, but only seen in 30-50% of SLE pts
-best diagnostic marker
Antihistone
DRUG INDUCED lupus (seen in 95%) and SLE
-esp from procainamide and hydralazine
sHIPPe- Sulfonamides, Hydralazine, Isonazid, Procainamide, Phenytoin, Etanercept
Rheumatoid Factor
(IgM that targets Fc of IgG)
RA (IgM against Fc portion of IgG)
*some Sjorgrens Syndrome!!! (may be + with or without arthritis in these patients)