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BCMB Previous Exam Questions

Terms in this set (17)

Which of the following is/are transient chemical interaction(s) contributing to protein structure and function?
Electrostatic interaction, hydrogen bond, van der Waals bond
What is the most important chemical property in folding of a water soluble protein?
Release of water to environment as the hydrophobic amino acids cluster in the interior of folded protein
Before a big biochemistry exam, one of your classmates freaks out from the stress and begins to hyperventilate. You try to calm him down by saying, "You are reducing the CO2 concentration in your tissue. Asa result...."
His146 in your hemoglobin (which can form a salt bridge with Asp94) is becoming deprotonated.
Which of the following amino acid residues would most likely be buried in the interior of a water-soluble, globular protein?
Valine
The secondary structure that is stabilized by backbone CO and NH hydrogen bonding within a peptide chain is the:
Alpha helix
What is the common strategy by which catalysis occurs?
Stabilization of the transition state
In the presence of oxygen, pyruvate is converted to _______________.
acetyl CoA
Where does the citric acid cycle take place in the cell?
mitochondria
_______________ is a large multi-subunit enzyme complex that links glycolysis and the citric acid cycle under aerobic conditions.
Pyruvate dehydrogenase
In aerobic organisms, the ultimate acceptor of electrons is:
O2
In aerobic metabolism, the final product of oxidation of carbon containing fuels is _______________.
CO2
The _______________ is the "energy currency" of metabolism.
ATP
Based on the parameters given in each choice, which reaction is least likely to be spontaneous?
one having Keq= 4 x 10^-2
Reactions that have positive standard free energy changes (deltaG>0) can be made to occur spontaneously in cells by:
Coupling them with exergonic reactions via a common intermediate, manipulating the concentrations of products and reactants such that deltaG<0, and coupling them to the hydrolysis of ATP
High levels of ATP and citrate:
Indicate a high-energy-well-fed state, promote gluconeogenesis, and inhibit glycolysis
The carbon skeletons for amino acid synthesis are intermediates found in __________.
glycolysis, the citric acid cycle, and the pentose phosphate pathway
The key citric acid cycle intermediate that is indicative of the fed state and used in acid synthesis is _____________.
citrate
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