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39 terms

BASAL GANGLIA - ANATOMY AND FUNCTION

NEUROSCIENCE - BASAL GANGLIA
STUDY
PLAY
WHAT CONSTITUTES THE BASAL GANGLIA?
CAUDATE, PUTAMEN, GLOBUS PALLIDUS, SUBTHALAMIC NUCLEUS, SUBSTANTIA NIGRA.
WHAT CONSTITUTES THE STRIATUM?
CAUDATE AND PUTAMEN & NUCLEUS ACCUMBENS?
WHAT CONSTITUTES THE LENTICULAR NUCLEUS?
PUTAMEN AND GLOBUS PALLIDUS
CORTICAL INPUT TO BASAL GANGLIA IS TO...?
THE STRIATUM AND SUBTHALAMIC NUCLEUS
OUTPUT NUCLEI OF THE BASAL GANGLIA ARE...?
GPi AND SUBSTANTIA NIGRA RETICULARIS
INTRINSIC NUCLEI OF THE BASAL GANGLIA ARE...?
GLOBUS PALLIDUS EXTERNAL (GPe) AND SUBSTANTIA NIGRA PARS COMPACTA
OUTPUT FROM BASAL GANGLIA IS...
GABAERGIC - INHIBITORY
INPUT TO THE BASAL GANGLIA IS...
GLUTAMINERGIC - FASCILITATORY
THE DIRECT INTERNAL PATHWAY OF THE BASAL GANGLIA INVOLVES:
INHIBITORY INPUT FROM STRIATUM TO GPi/SUBSTANTIA NIGRA RETICULARIS
HOW DOES THE DIRECT PATHWAY AFFECT BEHAVIOUR?
INHIBITION OF GPi/SNr REDUCES INHIBTION OF THALAMUS - FASCILITATES BEHAIOUR
THE INDIRECT PATHWAY OF THE BASAL GANGLIA INVOLVES:
INHIBITORY INPUT FROM STRIATUM TO GPe; INHIBITORY INPUT FROM GPe TO STN; FASCILITATORY INPUT FROM STN TO GPi/SNr
HOW DOES THE INDIRECT PATHWAY INFLUENCE BEHAVIOUR?
SUPPRESSES UNWANTED BEHAVIOUR
WHAT TYPE OF NEURONS DOMINATE THE STRIATUM, AND WHAT PERCENT?
95% MEDIUM SPINY INHIBITORY NEURONS
WHAT IS A PATCH OF MEDIUM SPINY NEURONS CALLED?
STRIOSOME
WHAT TYPE OF NEURON CONSTITUTES 5% OF STRIATUM?
ASPINY INTERNEURONS - EITHER GABAERGIC (MEDIUM) OR ACETYLCHOLINERGIC (LARGE)
WHAT EFFECT DOES A DORSAL CAUDATE LESION HAVE?
DYSEXECUTIVE SYNDROME; VISUOSPATIAL IMPAIRMENT (EARLY PARKINSONS)
WHAT EFFECT DOES A VENTRAL CAUDATE LESION HAVE?
DISINHIBITED BEHAVIOURS; ADDICTIVE BEHAVIOUR (FROM DOPAMINERGIC INPUT)
WHAT EFFECT DOES A PUTAMINAL LESION HAVE? (IN GENERAL)
HEMIPLEGIA
POSTERIOR PUTAMEN LESION?
WEAKNESS, SENSORY LOSS, IMPAIRED VISION
ANTERIOR PUTAMEN LESION?
MOTOR IMPERSISTENCE, UNILATERAL NEGLECT
RIGHT PUTAMEN LESION?
VISUAL NEGLECT
DESCRIBE THE INPUT TO GPe
INHIBITORY (GABA) FROM STRIATUM
EXCITATORY (GLUTAMATE) FROM SUBTHALAMIC NUCLEUS
DESCRIBE OUTPUT FROM GPe
PARVALBUMIN POSITIVE OUTPUT TO STN & GPi/SNr
PARVALBUMIN NEGATIVE TO STRIATUM.
GPe LESIONS RESULT IN:
ATTENTION DEFICIT AND HYPERACTIVITY
DESCRIBE THE FUNCTIONAL REGIONS OF THE SUBTHALAMIC NUCLEUS
DORSOLATERAL: MOTOR
MEDIAL: LIMBIC
VENTROMEDIAL: ASSOCIATIVE
DESCRIBE THE INPUTS TO THE STN
INHIBITORY (GABA) FROM GPe - RECIPROCAL
EXCITATORY (GLUTAMATE) FROM MOTOR CORTEX
DESCRIBE THE OUTPUTS FROM THE STN
EXCITATORY (GLUTAMATE) TO GPi/SNr AND GPe
LESION OF THE SUBTHALAMIC NUCLEUS RESULTS IN
CONTRALTERAL HEMIBALLISM
THE SUBSTANTIA NIGRA RETICULARUS IS RELATED TO THE MOVEMENT OF WHAT PART OF THE BODY?
EYES, HEAD AND NECK
THE GPi IS RELATED TO THE MOVEMENT OF WHAT PART OF THE BODY?
LIMBS, AXIAL
LESIONS TO THE GPi RESULT IN..?
SELF ACTIVATION DEFICIT
DOPAMINE ____ THE INDIRECT PATHWAY WITH ______ RECEPTORS
INHIBITS, D2 LIKE (D2,D3,D4)
DOPAMINE___ THE DIRECT PATHWAY WITH ____RECEPTORS
EXCITES, D1 LIKE RECEPTORS (D1, D5)
DOPAMINE _____ BEHAVIOUR
FASCILITATES
DESCRIBE THE PATHWAY OF THE LENTICULAR FASCICULUS
GPi TO THALAMUS VIA INTERNAL CAPSULE
DESCRIBE THE PATHWAY OF THE ANSA LENTICULARIS
GPi TO THALAMUS
DESCRIBE THE PATHWAY OF THE THALAMIC FASCICULUS
CEREBELLUM AND BASAL GANGLIA TO THALAMUS
DESCRIBE THE PATHWAY OF THE SUBTHALAMIC FASCICULUS
STN TO GLOBUS PALLIDUS VIA INTERNAL CAPSULE
WHAT ARE THE FIVE PARALLEL CIRCUITS OF THE BASAL GANGLIA?
1. MOTOR
2.OCULOMOTOR
3. DORSOLATERL PREFRONTAL (ASSOCIATIVE)
4. LATERAL ORBITOFRONTAL (ASSOCIATIVE)
5. LIMBIC