resting stage, no contraction. ADP + PI are bound to ATpase of mysosin. Myosin binding site of acti is covered by tropomyosin.
ca2+ binds to troponin, pulls troponin-tropomyosin complex off the myosin binding site of actin. Actin binds to myosin.
adp + pi are released from myosin atpase, acusing a change in the conformation of the myosin head. the thin filament is pulled toward the center of the sarcomere.
ATP binds to myosin ATPASE, which breaks the crossbridge
ATP is hydrolized into DP + PI and energy is released. This energy is used to swivel the myosin head back to its original conformation. myosin is now ready to form a new crossbridge with another actin protein if ca2+ and ATP are still available
are formed when ca2+ binds to troponin, troponin-tropomyosin complex is pulled off the binding site of actin. actin binds to myosin formin crossbridge
roles of atp and ca2+
ca2+ binds o troponin, which changes formation of tropomyosin, revealing binding site of actin. ATP binds to atpase and breaks crossbridge
asynchronous crossbridge formation
multiple crossbridges form and break asynchronously. keeps sarcomere shortening.