VACTERAL (vertebral, cardiac, limb, renal, etc), slight increase in transposition of great vessels, 30% higher, causes hypospadius (urethra of penis opens on shaft or at scrotum)
E2 replacement for miscarriage therapy, baby girls have a really high adenocarcinoma of vagina rate at 16-22yrs old if mom took it, male reproductive tract has issues too.
Ovulation inducer, anacephaly chances rise
Itself is harmless, but diabetic moms have vascular issues in general and baby gets caudal regression syndrome, where sacrum just doesn't form right, and the baby is HUGE because insulin is a growth factor to them. They go hypoglycemic the minute you cut their cord.
Not yet proven as a teratogen, but people are convinced they're bad somehow. It wrecks havoc in rats.
During the 3rd trimester, they cause early closure of the ductus arteriosis in the heart, so baby shunts blood to the lungs too soon!
Iodine crosses the placenta easily! Goiter is caused by too much KI around, Cretinism by not enough. Thyroxine is partially responsible for synapse formation.
Drug Classifications A, B, C, D, X
A = Controlled studies show no risk B = No evidence of risk in humans C = Risk cannot be ruled out D = Positive evidence of risk X = Studies prove risk - "Contraindicated in Pregnancy"
Folic Acid antagonists - highly teratogenic, produce anacephaly
A sedative, once thought to be a miracle morning sickness drug. Still used to treat leprosy. Causes amelia/meromelia, FDA in US never approved it thanks to a doctor from South Dakota :)
Anticonvulsant, for seizures, causes IUGR and cleft pallet/lip, and a very pointed eyebrow arch.
Anticonvulsant, for seizures, causes fetal hydantoin syndrome, IUGR, clift lip, distal digital hypoplasia.
Antibiotic, interferes with calcification, and stains baby's permanent teeth!
Antibiotic, congenital hearing loss. But it's really good at treating TB if mom has it...so sometimes it's worth it.
SAFE! Not a teratogen :)
Fetal Alcohol Syndrome Diagnostic Criteria: a) prenatal growth retardation and low birth weight b) reduced palpebral fissures c) Maxillary hypoplasia - "Indistinct philtrum" d) Mental deficiency of some sort (Ethanol a common cause) NO AMOUNT IS SAFE!
Abruptial Placenta risk high! Cerebral infarct - baby has a stroke in the womb.
IUGR, newborn's sleep patterns are odd
Hypoplasia of Calvaria - top of the skull doesn't close Microcephaly