The increase in PTH causes calcium to leave the bones and enter the blood, resulting in hypercalcemia making bone become weak and fragile and brittle
Excess PTH causes excretion of phosphate leading to hypophosphatemia
Many client are asymptomatic, bt when symptoms occur they affect the Musculoskeletal-chronic low bck pain, muscle weakness, decreased muscle tone, pathologic fracture
Renal- polyuria, renal calculi
GI system- abdominal pain, anorexia, nausea, constipation peptic ulcer
Cardiovascular- dysrhythmias, HTN
CNS- depression, impaired memory, psychosis, stupor, coma
and brittle nails
Musculoskeletal- muscle spasms, tremors, positive Chvosteck's sign, Trousseau's sign
Integumentary - hair loss, brittle nails, dry scaly skin
GI system- abdominal pain, cramps
CNS- numbness/ tingling in lips, hands, feet, irritability, depression, psychosis
With excess production of glucocorticoids, there are changes in CHO, protein and fat metabolism. There are fat deposits in the abdomen, fat pads under the clavicle, a "buffalo hump" over the upper back, and a round "moon" face. Easy brusing
Altered protein metabolism leads to muscle weakness and wasting in the extremities.
Excess cortisol causes loss of collagen and connective tissue, leading to poor wound healing.
Thinned skin stretches over the abdomen and buttocks, purple striae (stretch marks) appear.
Glucose metabolism is often altered and DM may occur
Decreased Ca aborption results in osteoporosis /compressed fractures of the vertebrae
Mineralocorticoid release promotes Na and H2O retention (FLUID)and K+ loss, leading to HTN
The inflammatory and immune responses are suppressed, greater risk for infection that can become life threatening
In women, increased androgen levels cause Hirsutism (excess facial hair), acne, and menstrual irregularities.
Emotional instability may range from depression to psychosis