What are the four types of communication between cells?
Direct communication, paracrine communication, endocrine communication, and synaptic communication
What is direct intercellular communication?
2 cells of the same type with extensive physical contact
What is paracrine intercellular communication?
use of chemical messengers to communicate between cells
What is a hormone?
a chemical messenger secreted into the bloodstream and transported to target cells in other parts of the body where they alter cellular activity
What is endocrine intercellular communication?
hormones coordinate cellular activity in distant parts of the body
What is synaptic intercellular communication?
quick communication between neurons with neurotransmitters
What three affects can a hormone have on a target cell?
1. increase production of enzymes and proteins through gene activation in the nucleus 2. decrease production of enzymes and proteins by affecting transcription or translation 3. turn an enzyme or channel on or off by altering its shape
How can you define the endocrine system?
all the cells and tissues that produce hormones or paracrine factors to effect other parts of the body
What is the difference between endrocrine and exocrine cells?
endocrine secretes into extracellular fluid and exocrine secretes through ducts onto epithelial surfaces
What are the three classes of hormones?
1. amino acid derivatives 2. peptide hormones 3. Lipid derivatives
What are two types of amino acid hormones? Give examples of each.
tyrosine (thyroid hormones and catecholamines: E, NE, and dopamine) and tryptophan (melatonin from the pineal gland)
What are the two categories of peptide hormones? Give examples of each.
glycoproteins (TSH, LH, and FSH from the pituitary gland) and Short polypeptides and small proteins (ADH, Oxytocin, GH, Prolactin)
What are the two categories of Lipid hormones? Give examples of each.
Eicosanoids (leukotrienes and prostaglandins) and Steroid hormones (androgens, estrogens, progestins, corticosteroids, calcitriol)
Once in the blood stream, what two courses of action may a hormone take?
can circulate freely or bind to a carrier protein
What is a second messenger?
it's triggered by the first messenger and it changes the rate of metabolic reactions
What are three common second messengers?
cyclic AMP (derivative of ATP), cyclic GMP (derivative of GTP), and calcium ions
Explain up regulation.
if there is an absence of a hormone that a cell needs, it will increase its number of receptors for that hormone thereby increasing its sensitivity to it
Explain down regulation.
If there is an overabundance of a hormone that a cell needs, it will decrease its number of receptors for that hormone thereby decreasing its sensitivity to it
When a G protein is activated by a hormone, it can activate cAMP. Describe this process.
1. G protein activates enzyme adenylate cyclase
2. Adenylate cyclase converse ATP to cAMP
3. cAMP activates kinase which attaches a high energy phosphate group to another molecule; phosphorylation
4. important enzymes are activated and ion channels are opened
When a G protein is activated by a hormone, it can open ion channels or release Ca ions from intracellular storage. Describe this process.
1. G protein activates phospholipase C (PLC) leading to a receptor cascade
2. Diacylglycerol (DAG) and inositol triphosphate are produced (IP3) from membrane phospholipids
3. IP3 diffuse into cytoplasm and triggers release of Ca2+ from intracellular reserves (in smooth ER)
4. DAG and intracellular Ca2+ activate membrane protein kinase C (PKC).
5. The activation of PKC leads to the phosphorylation of calcium channel proteins, which open the channel and allows extracellular Ca2+ to enter the cell
6. Protein calmodulin binds to Ca2+ and activates specific cytoplasmic enzymes
Which types of hormones bind to the cell membrane activating the G protein?
Catecholamines, peptide hormones, and eicosanoids
Lipid hormones can pass through the glycolipid bilayer of a cell membrane and bind to receptors inside the cytoplasm. What takes place from that point?
the hormone-receptor complex activates or deactivates specific genes in the nucleus altering the rate of transcription affecting protein synthesis
How do thyroid hormones affect cellular activity? (process)
1. they cross the cell membrane by active transport and bind to receptors in the nucleus and on mitochondria
2. those that bind to receptors in the nucleus change the rate of transcription which affects metabolic activity of the cell by increasing or decreasing enzymes
3. those that bind to mitochondria increase ATP production
What are regulatory hormones?
hormones secreted by the hypothalamus that affect the anterior lobe of the pituitary gland
What hormones does the hypothalamus synthesize and release into circulation within the pituitary gland?
oxytocin and ADH
What three mechanisms does the hypothalmus use to control the body's endocrine system?
1. secretion of regulatory hormones to the anterior lobe of the pituitary gland
2. production of ADH and oxytocin which it releases into the posterior lobe of the pituitary gland
3. control of the sympathetic output to adrenal medullae; affecting secretion of E and NE
The anterior lobe of the pituitary gland can be divided into three regions. What are those regions? Describe their locations.
1. Pars distalis- largest and most anterior portion
2. Pars tuberalis- extension wrapping around the infundibulum
3. Pars intermedia- a narrow band bordering the posterior lobe
What is the function of the hypophyseal portal system?
To transport regulatory hormones from the hypothalamus to the anterior lobe of the pituitary gland
What are portal vessels?
blood vessels that link 2 capillary networks (as in the hypophyseal portal system)
What is the function of the releasing hormones of the hypothalamus?
to stimulate synthesis and secretion of hormones in the anterior lobe of the pituitary gland
What is the function of the the inhibiting hormones of the hypothalamus?
to inhibit the synthesis and secretion of hormones in the anterior lobe of the pituitary gland
What are tropic hormones?
anterior lobe hormones whose purpose is to turn on other endocrine glands in the body
What hormones does the A.L.P.G. synthesize and secrete? (6)
TSH (thyroid stimulating hormone), ACTH (adrenocorticotropic hormone), Gonadotropins, PRL (Prolactin), GH (Growth Hormone), MSH (Melanocyte-stimulating hormone)
What does ACTH of the A.L.P.G. do?
stimulates the release of steroid hormones by the adrenal cortex (ie. glucocorticoids which affect glucose metabolism)
What do gonadotropins of the A.L.P.G. do?
regulates activities of gonads including reproductive cell and hormone production
What are the two kinds of Gonadotropins?
Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH)
What does FSH do for males and females?
males: sperm maturation
females: promotes estrogen secretion (ie estradiol)
What does LH do for males and females?
males: stimulates androgen production (ie. testosterone)
females: induces ovulation and promotes secretion of estrogen and progestin
Explain the two mechanisms by which GH accelerates protein synthesis resulting in cell growth and replication.
1. causes liver to make somatomedins or insulin-like growth factors (IGFs); these bind to cells and increase the uptake rate of amino acids and incorporation into new proteins.
2. stimulates stem cell divisions in epithelia and connective tissue; stimulates breakdown of triglycerides in adipose tissue and tissues break this down generating ATP
What is the diabeticogenic effect?
in the liver, GH stimulates the break down of glycogen reserves resulting in the elevation of glucose in the blood
What hormones regulate the secretion of GH?
Growth Hormone Releasing Hormone (GH-RH) and Growth Hormone Inhibiting Hormone (GH-IH) from the Hypothalamus
What does Melanocyte-stimulating hormone do?
stimulates melanocytes to produce melanin; however, this is non functional in adults because melanin is produced locally in the skin
What is another name for the Posterior Lobe of the Pituitary Gland?
Neurohypophysis because it contains axons of hypothalamus neurons
How and where are Oxytocin and ADH produced?
In the Hypothalamus, neurons, supraoptic and Paraventricular nuclei manufacture them and transport them to the posterior lobe of the pituitary gland
What triggers the release of ADH?
high solute concentration in blood or fall in the volume or pressure of blood
What function does ADH serve?
to decrease water loss at the kidneys thereby increasing blood volume and decreasing solute concentration of the blood
What does drinking alcohol cause frequent urination?
it inhibits ADH resulting in excessive water loss at the kidneys
What is diabetes insipidus?
posterior lobe does not secrete ADH; causes frequent urination and thirst
What is thyroglobulin?
the follicle cells produce this globular protein and secrete it into the colloid. These molecules contain tyrosine which forms thyroid hormones
Explain the process by which the thyroid gland synthesizes and secretes T3 and T4.
1. TSH opens follicle channels to admit I-
2. Iodide ions from the diet are transported into cytoplasm of follicle cells.
3. Iodide ions are converted to I+ by thyroid peroxidase; one or two I- are attached to thyrosine portion of thyroglobulin
4. These thyrosine-I- complexes form covalent bonds with one another to make thyroid hormones thyroxine T4 (has 4 I-) and Triiodothyronin T3 (has 3); These remain incorporated into thyroglobulin.
5. Follicle cells remove thyroglobulin from follicles by endocytosis
6. Lysosomal enzymes break thyroglobulin into amino acids and thyroid hormones.
7. T3 and T4 enter the bloodstream
8. Most T4 and T3 attach to thyroid-binding globulins; the rest attach to transthyretin
Explain the process by which T3 and T4 hormones affect target cells.
1. They bind to cytoplasmic receptors of target cells to affect storage
2. They bind to mitochondria to increase ATP production
3. they bind to receptors in the nucleus to accelerate the production of an enzyme responsible for the sodium-potassium pump
Why is most of the body's iodide reserve stored in the thyroid gland?
TSH stimulates iodide from the diet to be actively transported to thyroid follicle cells
When there is too much Ca+ in the blood, what do the thyroid glands produce?
C cells produce calcitonin which results in decreased Ca+ levels
What is the function of the chief cells?
to monitor Ca2+ levels in the blood; they act in opposition of C cells; while C cells respond to high levels of Ca2+ by secreting calcitonin, chief cells respond to low levels by secreting parathyroid hormone (PTH) which increases Ca2+
What effect does PTH have on the body? (specific)
1. stimulates osteoclasts and inhibits osteoblasts
2. enhances reabsorption of Ca2+ at the kidneys
3. stimulates calcitriol at kidneys which enhances Ca 2+ absorption at the digestive tract.
Why can a person not live without corticosteroids?
they are in charge of which genes are transcribed and at what rate
What are the three layers of the adrenal cortex from outermost to innermost?
zona glomerosa, zona fasciculata, zona reticularis
What hormone does the zona glomerosa produce?
mineralcorticoids (specifically aldosterone) which affect electrolyte levels in the blood
What do glucocorticoids do?
accelerate glucose synthesis and glycogen formation; anti-inflammatory- inhibits white blood cells; can be used to control allergies
Which hormone triggers the zona fasciculata to produce glucocorticoids?
adreno cortico tropic hormone from the anterior lobe of the pituitary gland
What hormones does the zona reticularis produce and what effect do they have on the body?
androgens that are converted to estrogens; stimulate pubic hair; important for muscle mass, blood cell formation and libido in adult women
Why is the adrenal medulla not a typical endocrine gland?
Its hormone production is triggered by the autonomic nervous system (sympathetic division)
How do the effects of E and NE differ from any other response from the sympathetic nervous system?
the effects last several minutes; other responses last mere seconds
What are the secretory cells of the pineal gland called and what do they secrete?
What is the function of melatonin?
1. inhibits reproductive function
2. protects against damage by free radicals
3. sets circadian rhythms
What hormone do the F cells of the pancreatic islets produce and secrete?
pancreatic polypeptide (PP)
What characterizes insulin-dependent cells?
they have insulin receptors and require insulin to absorb glucose
What characterizes insulin-independent cells and where are these cells located in the body?
they do not have insulin receptor and do not require insulin to absorb glucose; brain, kidneys, digestive tract, and red blood cells
What effect does insulin have on the cells it binds to?
stimulates glucose utilization to support growth and establishment of glycogen and triglyceride reserves
What effects does glucagon have on the body?
mobilizes glycogen reserves for use
1. stimulates the break down of glycogen in muscle and liver
2. stimulates the break down of triglycerides in adipose tissue
3. stimulates glucose production in liver
What triggers the release of Calcitriol from the kidneys?
low Calcium levels in the blood trigger the release of Parathyroid hormones which trigger the release of Calcitriol
What is Cholecalciferol?
Vitamin D that is synthesized in the skin when exposed to sun; can be converted to calcitriol
What effect does Calcitriol have on the body?
stimulates Calcium and Phosphate ion absorption along digestive tract
What triggers the production and release of Erithropoietin (EPO) by the kidneys?
low oxygen levels in the kidneys
What stimulates the production and release of Renin from the kidneys?
sympathetic stimulation and decline in kidney blood flow
What effect does Renin secretion from the kidneys have on the body?
increases blood pressure and volume by retricting salt and water loss at the kidneys
How are heart endocrine glands antagonistic to kidney endocrine glands?
Renin from the kidneys responds to low blood pressure and increases it; the heart's endocrine glands respond to high blood pressure and lower it
How do the endocrine cells in the heart detect high blood pressure?
They are cardiac muscle cells in the wall of the chambers; when blood volume increases, they get stretched and are mechanically triggered
What effect do natriuretic peptides have on the body?
they promote loss of Na+ and water at the kidneys, suppress thirst, and prevent E and NE from elevating blood pressure
What two types of endocrine cells are in a male's gonads?
1. interstitial cells
2. sustentacular cells
What effect does inhibin have on the body?
inhibits FSH and GnRH; supports differentiation and physical maturation of sperm
How does resistin correlate with obesity and diabetes?
Obese people have more adipose tissue that releases more resistin. Resistin causes less sensitivity to insulin resulting in higher blood sugar.
What is an integrative effect?
2 hormones produce a different but complementary effect (work well together)
What are the three phases of general adaptation syndrome in response to stress?
Alarm, Resistance, Exhaustion
What four results do endocrine secretions seek during the resistance phase of GAS?
1. mobilize lipid and protein reserves
2. conserve glucose so neural tissue can use it
3. glucagon and glucocorticoid stimulate the liver to manufacture glucose for the blood stream
4. conserve blood volume
What complications end the resistance phase?
lipid exhaustion, glucocorticoids cause problems with immune system, high blood volume stresses the cardiovascular system, adrenal cortex cannot produce any more glucocorticoids