INACTIVATES Ras; Activates Ras GTPase activity, causing GTP to be hydrolyzed; Ras-GAP keeps most of the Ras inactive
GEF ACTIVATES Ras; Causes Ras to eject GDP, so that it can binds free GTP
Inability to hydrolyze GTP, thus it would be constitutively active! Increasing cell proliferation
What does Ras-GAP do?
What does Ras-GEF do?
What would a mutation of Ras lead to?