#42 Scleroderma

1 / 25
Scleroderma is a disorder of ____, skleros means ____
it has an unknown etiology
Click the card to flip 👆
Terms in this set (25)
telengectasias are ____dilated peripheral blood vesselsmost likely other diseases associated with scleroderma ___ and ___polymyositis Lupusscleroderma epidemology most likely in: age and gender, ethnicitywomen of childbearing age native americansScleroderma is associated with ___ genes, may have a link to ___ dysfunction, like it is in miceHLA D (Q7 and R5) fibrillinskin biopsy in scleroderma will have increased ___collagenWhat drug can trigger scleroderma skin changebleomycinnon-specific marker that can be seen in scleroderma ___ANAscleroderma pathogenesis has B cells and Ig in circulation that are ____, which eventually induce ___autoantibodies fibrosisin scleroderma the vascular endothelium is ___ by destructive ___ factor which causes ___ proliforationdamaged platelet derived growth factor smooth muscleendothelial cells make endothelin which increases ___ which increases the synthesis of collagen which is unwantedfibroblastsnailfold capillaroscopy in sclerodermal will showincrease in dilated blood vesselsmost important sclerodermal vascular injury which is an emergency: ___, which leads to high ___ and reduced ___sclerodermal renal crisis blood pressure output of urinethe most important cytokine mediating transcriptional changes that lead to collagen over-synthesis is: ___ in sclerodermatransforming growth factor betaskin histology in scleroderma: thickened ___ and increased ___dermis collagenleading cause of death in scleroderma: ___ involvement, when you have this involvement, mean survival is 2 yearslung