renal buzzwords


Terms in this set (...)

LM - enlarged, hypercellular glomeruli; IF - granular appearance due to IgG, IgM, C3 deposition; EM - subepithelial immune complex humps
poststreptococcal GN, nephritic
LM and IF - crescent moon shapes consisting of fibrin and plasma proteins
rapidly progressive GN, nephritic
LM - "wire looping" of capillaries, EM - subendothelial and intramembranous IgG-based immune complexes often with C3 deposition; IF - granular
diffuse proliferative GN, nephritic (most common cause of death in SLE, think "wire lupus")
LM - mesangial deposition; EM - mesangial immune complex deposits; IF - immune complex deposits in mesangium
IgA nephropathy, nephritic (Berger disease, renal pathology of Henoch-Schonlein purpura)
mutation in type 4 collagen --> thinning and splitting of glomerular basement membrane
Alport syndrome, nephritic ("can't see, can't pee, can't hear a buzzing bee" - eye problems, glomerulonephritis, sensorineural deafness)
"basket weave" appearance on EM
alport syndrome, nephritic
subendothelial deposits with granular IF; "tram track" appearance on PAS stain and H&E stain due to GBM splitting caused by mesangial ingrowth
membranoproliferative GN type 1, nephritic (often copresents with nephrotic syndrome)
intramembranous immune complex deposits, "dense deposits"
membranoproliferative GN type 2, nephritic (associated with C3 nephritic factor)
LM - segmental sclerosis and hyalinosis; IF - nonspecific for focal deposits of IgM, C3, C1; EM - effacement of foot processes similar to MCD
focal segmental glomerulosclerosis, nephrotic (most common cause of primary nephrotic syndrome in African Americans and Hispanics)
LM - normal; IF - negative; EM - effacement of foot processes
minimal change disease, nephrotic (aka lipoid nephrosis, most common cause of nephrotic syndrome in children, may be caused by infection, primary disease has excellent response to steroids)
LM - diffuse capillary and GBM thickening; IF - granular as a result of immune complex deposition; EM - "spike and dome" appearance with subendothelial deposits
membranous nephropathy, nephrotic (most common cause of primary nephrotic syndrome in Caucasians; triggers - Abs to phospholipase A2, NSAIDS, penicillamine, infections - HBV, HCV, SLE, solid tumors)
LM - mesangial expansion, GBM thickening, eosinophilic nodular glomerulosclerosis
diabetic glomerulonephropathy, nephrotic (due to nonenzymatic glycosylation of GBM and efferent arterioles)