Terms in this set (27)
Drugs the produce a response
Drugs that block a response
The margin of safety of a drug.
Peak Drug Level
The highest plasma concentration of a drug at a specific time. Indicates the rate of absorption
Trough Drug Level
Lowest plasma concentration of a drug, measures the rate at which the drug is eliminated.
An immediate and large initial dose to produce a rapid response.
The scientific study of how the effect of a drug action varies from a predicted response because of genetic factors and hereditary things.
A decreased responsiveness over the course of therapy
A rapid decrease in response to the drug. An "acute tolerance"
A psychological benefit from a compound that doesn't have the chemical effect of an actual drug.
3 Phases of Drug Action
When the drug is absorbed in the GI tract. SubQ, IM, and IV medications don't have a pharmaceutic phase.
The breakdown of a tablet into smaller particles
The dissolving of the smaller particles in the GI fluid before absorption.
The time it takes for the drug to disintegrate and dissolve so the body is able to absorb it.
The process of drug movement to achieve drug action.
The movement of drug particles from the GI tract to body fluids.
The process by which the drug becomes available to body fluids and body tissues. Influenced by blood flow, the drugs liking to the tissue, and the protein-binding effect.
Drugs are primarily metabolized in the liver but can also be in the GI tract.
The time it takes for one half of the drug concentration to be eliminated. Liver or kidney dysfunction can cause the half-life to be prolonged and less drug is metabolized and eliminated.
Mainly through the kidneys. Also through bile, feces, lungs, saliva, breast milk and sweat.
Test that determines renal function. If creatinine clearance is high the drug dose needs to be decreased.
The study of drug concentration and it's effects on the body. Drug response can cause a primary or secondary physiological effect. Primary effects is what the drug is supposed to do and the secondary effects are either desirable or undesirable.
Onset of action
The time it takes the drug to reach the minimum effective concentration (MEC) after a drug is administered.
When the drug reaches it's highest blood or plasma concentration.
Duration of action
The length of time the drug has a pharmacologic effect.
Evaluates the onset of drug action, peak actions, and duration of action.
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