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Non Specific Immune System
1. Barrier Defenses 2. Inflammatory Defenses 3. Cellular and Molecular Defenses
• Histamine is released at the sign of damage • Blood vessels leak fluid and White Blood Cells
• Macrophages- use pocket transport (phagocytosis) to destroy foreign particles • Natural Killer Cells release hydrolytic enzymes onto target cells to rupture/destroy them
• Interferon- anti-viral • Complement- "glue" - only sticks to pathogens, prevents pathogens from entering cells
White Blood Cells: •Helper T cells •Killer T cells • B cells (plasma/memory) •Macrophage
Searches body tissues for pathogens, consumes pathogens with phagocytosis, kill pathogen with lysosomes, display antigens, now an APC, signals helper T
chemically signaled by macrophage, "lock-key"- right helper t must have CD 4 receptor that fits atigen, when helper t fits antigen, helper t activates and releases cytokines which causes lymphocytes to start mitosis
Cell Mediate Response
virus explodes out of cell, antigen put into MHC 1 receptor, killer t binds to antigen, releases perforin, perforin ruptures infected cell membrane, exposes virus to other immune cells
receptors: antibodies, different b cells have uniquely shaped antibodies to match specific antigen
b cells antibody binds with antigen (lock-key), b cell receives a message from helper t to activate, activated b cells divide into plasma and memory
produce and secrete 10,000 "keyed" antibodies per hour, each can bind to several antigens at once, has 3 effects
don't actively produce antibodies, remain in blood stream and maintain their cell life cycle independently of helper t, if anitgen enters body again cells recognize it and react quickly releasing antibodies that are "keyed" for that antigen
Helper T and Killer T Memory
Remain in blood stream, when antigen returns into blood stream cells recognize antigen and react quicker
Lymphocytes cannot distinguish between your cells and foreign cells, attack your own healthy cells
Your cells kill the insulin producing cells in your pancreas- body cannot digest glucose
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