Create an account
What cellular enzymes do fluoroquinolones inhibit?
DNA topoisomerases (either DNA gyrase aka topoisomerase II in gram negatives or topoisomerase IV in gram positive)
What is the role of DNA gyrase II versus DNA topoisomerase IV
Bacterial DNA is negatively coiled; DNA gyrase introduces positive supercoiling whereas DNA topoisomerase introduces negative supercoils and decatenates the DNA
Binds to the GyrA-DNA complex and stabilizes it so arrests the progression of coiling and is thus bacteriostatic; later on, due to the accumulation of double stranded breaks, it is bacteriocidal
How does resistance to fluoroquinolones arise?
Mutation of chromosomal target; low level of plasmid-encoded protein sinks common in mycobacteria
Clinical use of fluoroquinolones?
UTIs, prostatitis, pen-resistant STDs, drug resistant M. tuberculosis, community acquired pneumonia, Salmonella and E coli diarrhea
Please allow access to your computer’s microphone to use Voice Recording.
Having trouble? Click here for help.
We can’t access your microphone!
Click the icon above to update your browser permissions and try again
Reload the page to try again!Reload
Press Cmd-0 to reset your zoom
Press Ctrl-0 to reset your zoom
It looks like your browser might be zoomed in or out. Your browser needs to be zoomed to a normal size to record audio.
Please upgrade Flash or install Chrome
to use Voice Recording.
For more help, see our troubleshooting page.
Your microphone is muted
For help fixing this issue, see this FAQ.
Star this term
You can study starred terms together