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In addition to hepatic, renal, & enzymatic metabolism, these organs often have a significant role in the metabolism of IV induction agents, particularly propofol?
What happens to etomidate upon entry to the cell?
It undergoes molecular rearrangement, where lipid solubility increases (similar to versed)
Etomidate causes ____ of _____ ____ ____ for up to 8 hours.
suppression of adrenocortical hormone synthesis
What does ketamine produce?
'Dissociative anesthesia' by inhibiting thalamocortical pathway/stimulating limbic system
Why should ketamine be used cautiously in patients w/ cardiac complications & CAD?
Increases workload on the heart & O2 consumption
What do barbiturates induce?
Reverse cerebral steal (Robin Hood effect) & free radical scavenging = neuroprotective
In what patients are barbiturates contraindicated?
Asthmatics (histamine release), & intermittent porphyria
Are benzos lipid or H20 soluble?
Mostly lipid soluble except midazolam (H20 soluble until encountering the body's pH at the lipid bilayer)
In regard to metabolism, what does diazepam & lorazepam produce and what is the effect?
How does one treat an intraarterial barbiturate injection?
Heparin, papaverine, lidocaine, phentolamine, or sympathectomy
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