Create an account
Mechanisms for drugs crossing membranes
1. passive diffusion
2. facilitated diffusion
3. active transport
Disadvantages of Oral Administration of drugs
slow, less predictable, first-pass metabolism, patient compliance
Absorption after oral administration is influenced by...
Route of Oral Administration (before reaching systemic circulation)
1. passes through stomach (acid stable)
2. diffuses from lumen through cells into blood stream
3. drug metabolism in gut wall and/or liver (aka "first-pass metabolism")
Enteral (absorb through GIT)
Parenteral (absorb outside of GIT)
Volume of Distribution
The apparent volume into which drug is distributed after IV injection
Vd = D/C0
where: Vd is volume in liters
D is dose of drug in mg
C0 is concentration (mg/L)
Please allow access to your computer’s microphone to use Voice Recording.
Having trouble? Click here for help.
We can’t access your microphone!
Click the icon above to update your browser permissions and try again
Reload the page to try again!Reload
Press Cmd-0 to reset your zoom
Press Ctrl-0 to reset your zoom
It looks like your browser might be zoomed in or out. Your browser needs to be zoomed to a normal size to record audio.
Please upgrade Flash or install Chrome
to use Voice Recording.
For more help, see our troubleshooting page.
Your microphone is muted
For help fixing this issue, see this FAQ.
Star this term
You can study starred terms together