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17 terms

Adrenal Cortex: 3 Layers

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three layers of Adrenal cortex
Zona Glomerulosa
Zona Fasciculata
Zona Reticularis
Zona Reticularis
Innermost layer of the cortex
Produces adrenal sex hormones
Most are androgens that are converted to testosterone in tissue cells or estrogens in females
Zona Fasciculata
Middle zone of the cortex
Zona Glomerulosa
Most superficial layer of the cortex
Zona Glomerulosa
Produce mineralocorticoids
Zona Glomerulosa
Regulates electrolytes/minerals, Na+ and K+ in extracellular fluid
Zona Glomerulosa
Na+: most important cation in the ECF
Where Na+ travels, so goes water
Changes in Na+ concentration impacts changes in blood volume/pressure
Zona Glomerulosa
Most potent mineralocorticoid: aldosterone
Zona Glomerulosa
K+: sets RMP of cells
Zona Glomerulosa
Determines ease of AP generation threshold
Zona Fasciculata
Secretes metabolic hormones, glucocorticoids (cortisol)
Zona Fasciculata
Functions include metabolic, developmental, and anti-inflammatory
Zona Fasciculata
Release is based on negative feedback system
Zona Fasciculata
Stress (due to cortisol) triggers rise in blood glucose
Zona Fasciculata
Gluconeogenesis functions to "save" glucose for the brain
Zona Fasciculata
Cortisol $ gluconeogenesis from fat/proteins
three layers of Adrenal cortex
produce corticosteroids; Synthesis begins with cholesterol; Steroid hormones are not stored; Rate of release depends upon rate of synthesis