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Malignant tumor of the deep soft tissue of lower extremities and retroperitineum: 40-60 yrs.
Has characteristics of malignancy but is benign.
Rapidly growing, poorly defined, fibroblasts are arranged randomly
Superficial fibramatosis lesion
nodules of fibrous tissues with poorly defined fascicles.
Palmar, Plantar, Penile.
No mutations of APC or beta-catenin.
Deep fibromatosis lesion
rapidly growing with infiltrative features.
Associated with APC or beta-catenin genes.
Recurrent but not necessarily malignant.
malignant and rare.
Herring bone pattern
May arise as radiation induced sarcoma or post burn scar
Herring bone pattern
Classical of fibrosarcoma. Hyperchromatic nuclei with increases N/C ratio. Spindle shaped
benign fibrous tumor in skin with histocytes. Storiform (pinwheel) pattern. Foam cells.
malignant soft tissue tumor which used to be considered most common sarcoma of adults. More common in males. Storiform architecture. Use IHC stains
Malignant Skeletal muscle tumor. Most common in adolescents. Aggressive. 3 types: embryonal, alveolar, pleomorphic
most common rhabdomyosarcoma. Grapes in vagina. Affects the cambium layer.
Worst prognosis of rhabdomyosarcoma. Central cells degenerate, drop out, and then look like alveoli cells. Midadolescents
Proximal portions of the extremities. Large multi-nucleated eosonophilic tumor cells
20-40 years old. Develop on lower extremities (knee and thigh). May have calcifications that can be seen on x-ray/ Biphasic
myophagocytosis which causes muscle distrophy and collagen deposition and fatty infiltration
most common adult muscular dystophy. Type 1 fibers atrophy. Facial muscle weakness
inflammatory disease of skin. Lilac/heliotrope skin rash. Upper eyelids with periorbital edema. Capillaries attacked by antibodies
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