TG drives cholesterol ester transfer via CETP (> 1.5 mmol/l ?) :
1) TG exchange reduces HDL-C and impairs reverse cholesterol transport. TG and HDL-C are inversely correlated
2) TG exchange causes smaller, denser LDL. When TG is raised, LDL-C underestimates CVD risk.
3) Small, rather than large, TG-rich particles may carry cholesterol into the artery wall. The linear relationship between TG and CVD risk declines at very high levels