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Anatomy and Physiology (Paramedic)
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Gravity
Terms in this set (534)
Frontal (coronal) plane
front and back
Transverse (axial) plane
top and bottom
Sagittal (lateral) plane
left and right
Midsagittal plane
(midline) left and right equal halves
Axillary
pertaining to armpit
Brachial
pertaining to upper arm
Buccal
pertaining to cheek
Cardia
pertaining to heart
Cervical
pertaining to neck
Cranial
pertaining to skull
Cutaneous
pertaining to skin
Deltoid
pertaining to shoulder
Femoral
pertaining to thigh
Gastric
pertaining to stomach
Gluteal
pertaining to buttocks
Hepatic
pertaining to liver
Inguinal
pertaining to groin
Lumbar
pertaining to lower back
Mammary
pertaining to the breast
Nasal
pertaining to nose
Occipital
pertaining to inferior posterior region of the head
Orbital
pertaining to the bones surrounding the eye
Parietal
pertaining to superior posterior region of the head
Patellar
pertaining to the front of the knee
Pectoral
pertaining to the chest
Perineal
pertaining to the perineum
Plantar
pertaining to sole of foot
Popliteal
pertaining to posterior knee
Pulmonary
pertaining to lungs
Renal
pertaining to kidneys
Sacarl
pertaining to sacrum
Temporal
pertaining to temples of skull
Umbilical
pertaining to navel
Volar
pertaining to sole of foot or palm of hand
Flexion
moving the distal part of a limb closer to the trunk
Extension
moving the distal part of a limb farther from the trunk
Recumbent
refers to any position in which pt is lying down or leaning back
Trendelenburg position
body is supine with head lower than feet
Recovery position
-aka. left lateral recumbent position
-maintains airway in unresponsive pt
Atomic numbr
number of protons in an atom
Atomic weight
protons + neutrons
Isotope
when an element's atoms have unequal protons and neutrons
Synthesis reaction
=reaction that occurs when two or more reactants (Atoms) bond to form a more complex product or structure
-Example: A + B -> AB
-important for growth and repair
Decomposition reaction
=reaction that occurs when bonds within a reactant molecule break and form simpler atoms, molecules, or ions
-Example: AB -> A + B
-important for decomposition and digestion
Exchange reaction
=reaction where parts of reacting molecules are shuffled around to produce new produces
-example: AB + CD -> AD + CB
Reversible reaction
=reaction where the products of the reaction can change back into the reactants they originally were
-Example: A + B <-- --> AB
Enzyme
promotes chemical reactions by lowering activation energy requirements
Electrolyte
-substances that release ions in water
-salt or acids
-chemicals dissolved in blood
Organic substances
-carbohydrates
-lipids
-proteins
-nucleic acids
Ways that material can pass thru the cell
-simple diffusion
-osmosis
-facilitated diffusion
-active transport
Microtubule
hollow filamentous structures that make up various components of a cell and provide movement of the cell, such as flagella and cilia
Meiosis
specialized cell division that produces sperm and egg
Types ot tissue
-epithelial
-connective
-muscle
-nervous
Mitosis
division of the nucleus of a cell
Cytokinesis
division of the cytoplasm of a cell
Active transport
-method used to move compounds across a cell membrane
-against concentration gradient
-required ATP
ATP
-major source of energy for all chemical reactions in body
Adipose tissue
type of connective tissue containing large amounts of fat
Antecubital fossa
anterior surface at the bend of the elbow
Anterior triangle
area of neck that is bordered by sternocleidomastoid muscle, anterior midline of the neck, and the inferior border of the mandible
Appendicular region
division of the skeletal system that includes the extremities and their attachments to the body
Axial region
a division of the skeletal system that includes the head, neck, and trunk
Axilla
armpit
Axons
extension off of a nerve cell body that conducts impulses to adjacent cells
Basement membrane
noncellular layer in an epithelial cell that anchors the overlying epithelial tissues
Cardiac muscle
-striated
-involuntary
-has capacity to generate and conduct electrical impulses
-branched
Carotid triangle
area of anterior triangle of the neck that contains the carotid artery and internal jugular vein
Cell membrane
-cell wall
-selectively permeable layer surrounding insides of cell
-controls movement of substances in and out of cell
Centriole
organelles that are essential in cell division
Chromosomes
structures containing DNA within cell's nucleus
-Humans have 23 pairs
Cilia
hair-like microtubule projections on the surface of a cell that can move materials over the cell surface
Columnar epithelium
Cranial cavity
hollow portion of the skull
Crenation
shrinkage of a cell that results when too much water leaves a cell thru osmosis
Cuboidal epithelium
Cytosol
clear liquid portion of cytoplasm
DendriteDiffusion
process where molecules move from area of higher concentration to area of lower concentration
Endocytosis
uptake of material thru cell membrane by membrane-bound droplet or vesicle formed within cell's cytoplasm
Endoplasmic reticulum
site of protein and lipid synthesis
Extracellular fluid (ECF)
-fluid outside of cell
-most of body's supply of sodium is here
-accounts for 15% of body weight
Girdle
bony structures that attach the limbs to the body
Golgi apparatus
-set of membranes in cytoplasm
-formation of sugars and complex proteins
Hyperkalemia
excessive potassium in blood
Hypernatremia
excessive sodium (greater than 145mEq/L)
Hyperosmolar hyperglycemic nonketonic coma (HHNC)
-diabetic emergency that occurs from relative insulin deficiency
-hyperglycemia, hyperosmolarity, absence of significant ketosis
Hypokalemia
low potassium in blood
Hyponatremia
serum sodium level less than 135 mEq/L
Intracellular fluid
-fluid inside cell where more of potassium is contained
-45% of total body weight
Lysis
process of disintegration of breakdown of cells that occurs when excess water enters the cell through osmosis
Lysosome
membrane bound vesicles that contain variety of enzymes functioning as cell's digestive system
Mediastinum
space between lungs that contains heart, trachea, mainstream bronchi, part of esophagus, and large blood vessels
Neuroglia
-connective and supporting tissues of nervous tissue
-one of two types of neural tissue
-support, protect, defend, and aid in repair of neural tissue
-also regulate composition of nervous system interstitial fluid
Nucleoli
round, dense structures that contain RNA and synthesize proteins
Osmosis
movement of solvent, such as water, from an area of low solute concentration to one of high concentration
Osmotic pressure
measure of the tendency of water to move by osmosis across a membrane
Parietal portion
portion of the serous membrane that lines the walls of the trunk cavities
Pericardial cavity
region around the heart
Pericardial effusion
abnormal accumulation of fluid within pericrdial sac
Pericardial sac
lubricated potential space btwn layers of pericardium
pericardial tamponade
condition that occurs as fluid accumulates around the heart, which restrict the heart's stroke volume
Pericardium
membrane surrounding the heart
Peritonitis
inflammation of peritoneum
Peritoneum
protective membrane that lines the abdominal and pelvic cavities
Pinocytosis
when cell ingests extracellular fluid and its contents
Pleura
serous membranes covering lunds and lining of thoracic cavity
Pleural space
space btwn visceral and parietal pleura
Pleural effusion
excessive accumulation of fluid within pleural space
Pleural fluid
small amount of lubricating fluid that fills pleural space
Pneumothorax
abnormal accumulation of air within pleural space
Pseudostratified epithelium
single layer of epithelial cells of varying heights that attach to basement membrane (do not reach free surface)
Retroperitoneal space
area located posterior to parietal peritoneum that contains kidneys, pancreas, reproductive organs, duodenum, and major blood vessels
Ribosomes
organelles that contain RNA and protein
Serous membranes
membranes that line body cavities that lack openings to outside
Skeletal muscle
-voluntary muscle
-striated
-light and dark striations
Smooth muscle
-nonstriated
-involuntary
-found in vessel walls, glands, and GI tract
-visceral and multiunit (two types)
Sodium-potassium exchange pump
mechanism that uses active transport to move sodium out and potassium in
Spindle fibers
microtubules radiating from centrioles
Squamous epithelium
-Flat sheets of epithelial cells
Stratified epithelium
multiple layers of cells
Transitional epithelium
=tissues that changes in appearance due to tension
-lines urinary bladder, ureters, and superior urethra
Ligament
bone to bone
Tendon
muscle to bone
types of joints
amphiarthrosis, diarthrosis, synarthrosis
Two types of bone
(1) compact
-solid
(2) Cancellous
-trabecular bone
Two parts that make up the skeleton
-axial
-appendicular
Axial skeleton
includes skull, hyoid bone, vertebral column, thoracic cage
How many bones make up the skull?
28 bones
Facial bones
include maxillae, zygomatic bones, nasal bones, vomer bone, inferior nasal conchae, lacrimal bones, palatine bones, and mandible
How many pairs of ribs?
-12 pairs of ribs
-2 floating pairs of ribs
Parts of sternum
-body, manubrium, xiphoid process
Appendicular skeleton
-contains upper and lower limb bones and bones anchoring limbs to ______skeleton
-includes shoulder girdle (clavicle and scapula), upper limbs, pelvic girdle, and lower limbs
Talus
bone in foot that articulates with tibia and fibula to form ankle joint
Calcaneus
-bone that is inferior and lateral to the talus
-provides support for standing
Acetabulum
depression on lateral pelvis that articulates with femoral head
Acromioclavicular joint
point at which the clavicle attaches to the acromion process
Acromioclavicular separation
injury caused by distraction of the clavicle away from the acromion process of the scapula
Anulus fibrosis
ring of fibrous or fibrocartilaginous tissue that is part of the intervertebral disk
Appositional growth
formation of new bone on the surface of a bone
Atlas
C1 and supports head
Axis
C2; allows head to turn
Battle sign
-bruising over mastoid process
-usually due to basilar fracture
Bruxism
grinding together of upper and lower teeth
Bursae
small fluid-filled sacs located between a tendon and a bone to help lubricate two surfaces that are rubbing together
Callus
zone of repair in which a mass of exudates and connective tissues forms around a break in a bone... heals
Carpal tunnel syndrom
caused by compression of median nerve
Carpals
-Scaphoid
-Lunate
-Triquetrum
-Pisiform
-Trapezium
-Trapezoid
-Capitate
-Hamate
Central disk herniation
-most serious disk rupture that occurs when nuclear material protrudes straight back into spinal canal
-potential to cause neurological injury
Chondroblast
cell that produce cartilage
Compression fracture
fracture of vertebral body associated with collapse of the body
Costochondritis
inflammation of costal cartilage (Attaching ribs to sternum)
Cribriform plate
bones in skull cavity that are perforated with foramina for the passage of olfactory nerve filaments from nasal cavity
Cristagalli
bony ridge where meninges are attache
Diaphysis
shaft of long bone
Endosteum
layer that lines inner surfaces of bone
Epicondylitis
-inflammation of muscles of elbow joint
-aka. tennis elbow
Fibroblasts
cells that secrete proteins and collagen to form connective tissue between broken bone ends and at other sites of injury throughout the body
Glenoid fossa
part of scapula that forms socket for shoulder joint
Herniated disk
tear in anulus fibrosus that results in leakage of nucleus pulposus, most commonly against exiting nerve roots
Hydroxyapatite
mineral compound containing calcium and phosphate that make up bone
Lordosis
inward curvature of lumbar spine
Meninges
-dura mater
-arachnoid
-pia mater
Ossicles
-thee small bones in middle ear; include malleus, incus, and stapes
-transmit vibrations to the cochlear duct at the oval window
osteogenesis imperfecta
a genetic bone disease that results in fragile bones
osteomalacia
an abnormal softening of bones because of loss of calcium
Osteomyelitis
inflammation of the bone and muscle caused by infection
Osteons
units within a compact bone in which blood vessels are located; also called haversian system
Osteroporosis
reduction in quantity of bony tissue
rickets
a disease caused by vitamin D deficiency
scoliosis
sideways curvature of the spine
Trismus
-involuntary contraction of the mouth resulting in clenched teeth
-occurs during seizures and head injuries
Myofibrils
-threadlike structures that extend from one end of the muscle fiber to the other
-located within individual muscle cells
Fasciculus
group of muscle fibers that are bundles with connective tissue
What are important components of contraction of muscles?
calcium and ATP
Two types of smooth muscle
-visceral
-multiunit
Synergists
muscles that work together to accomplish a particular movement
Antagonists
muscles that work in opposition to one another
Acetylcholine
chemical neurotransmitter that serves as a mediator in bother sympathetic and parasympathetic nervous system
Acetylcholinesterase
enzyme that causes muscle relaxation by helping to break down acetylcholine
Achilles tendon
strong tendon that joins the muscles in the posterior leg to the calcaneus
Actin
component that makes up most of thin filaments of the myofibrils
Agonist
-prime mover
-muscle that contracts to provide mose of a desired movement
Aponeurosis
broad sheet of fibers that may attach to bones or coverings of other muscles
Bell palsy
condition caused by damage to the facial nerve resulting in an inability to move facial muscles on the affected side
Calmodulin
an intracellular protein to which calcium binds, resulting in muscle contraction
Compartment syndrome
-accumulation of blood or fluid in fascial compartment resulting in compression of blood vessels and tissue
-usually result of trauma
-can cause death of muscle and loss of limb
Creatine phosphate
an organic compound in muscle tissue that can store and provide energy for muscle contraction
Fascia
layer of fibrous connective tissue outside the epimysium that separates the individual muscles and individual muscle groups
gap junctions
conduction areas between cells (e.g., in visceral smooth muscle) that interconnect individual muscle cells
Intercalated disks
branching fibers in cardiac muscle that allow action potentials to pass from cell to cell
Intrinsic automaticity
ability of a muscle to generate its own electrical activity
Lactic acid
end produce of the breakdown of glucose that accumulates when metabolism proceeds in the absence of oxygen
motor end plate
flattened end of a motor neuron that transmits neural impulses to a muscle
Multiunit smooth muscle
-one of two types of smooth muscle
-formed into sheets of muscle (as in the walls of blood vessels), small bundles of muscles (as in the iris of the eye), or single cells (as in the capsule of the spleen)
Oxygen debt
the amount of oxygen that liver cells need to convert lactic acid into glucose, as well as the amount needed by muscle cells to restore adenosine triphosphate and creatine phosphate levels
Sarcolemma
thin transparent sheath surrounding striated muscle fiber
Sarcomere
repeating patterns of striation units that appear along each skeletal muscle fiber
synaptic cleft
space between neurons
Thompson test
test used to evaluate the integrity of the achilles tendon for possible rupture
tropomyosin
actin-binding protein that regulates muscle contraction and other actin related mechanical function of the body
troponin
a regulatory protein in the actin filaments of skeletal and cardiac muscle that attaches to tropomyosin
Visceral smooth muscle
sheets of muscle that are found in the digestive, reproductive, and urinary tracts
Yergason test
supination of the forearm against resistance to evaluate whether a pt has bicipital tendinitis
primary functions of respiratory system
-intake of oxygen
-removal of carbon dioxide
-exchange of gases and ventilation
Flow of air
-enters at nasopharynx or oropharynx
-moves to trachea
-bronchi
-bronchioles
-alveoli in lungs
Upper airway
-mouth
-nasopharynx
-oropharynx
Nasopharynx and oropharynx (start to end point)
-Naso extends from the internal nares to the uvula
-Oro extends from the uvula to the epiglottis
Lower airway
-starts at larynx
-includes glottis, vestibular folds, vocal cords, bronchi, and bronchioles
external respiration
gas exchange between air in the lungs and the blood
Internal respiration
gas exchange between blood and the cells
Where do lungs receive blood from?
-right ventricle via pulmonary arteries
-bronchial arteries (which branch from thoracic aorta)
Respiratory area of the brain
-brainstem, pons, medulla oblongata
-stimulated by CO2 in blood (and lesser effect of O2 levels in blood)
Abestosis
disease of the lungs caused by inhalation of asbestos particles
Asthma
chronic inflammatory lower airway condition resulting in intermittent wheezing and excess mucus production
Bicarbonate ions
-ions related to carbonic acid
-formed from carbon dioxide transport mechanisms
Black lung disease
disease of the lung caused by consistent inhalation of coal dust
Bronchial veins
veins that return deoxygenated blood to the heart from the lungs
Carbaminohemoglobin
bonding of carbon dioxide with hemoglobin
Carbonic anhydrase
an enzyme in rbcs that speeds the reaction of carbon dioxide and water, resulting in carbonic acid
Carina
ridgelike projection of tracheal cartilage located where the trachea bifurcates into the right and left mainstem bronchi
Chronic obstructive pulmonary disease (COPD)
progressive and irreversible disease of airway marked by decreased inspiratory and expiratory capacity of the lungs
Emphysema
-infiltration of any tissue by air or gas
-COPD (disease) characterized by distention of the alveoli and destructive changes in the lung parenchyma
Functional residual capacity
expiratory reserve volume plus residual volume
Glottis
vocal cords and the openings between them
Hilum
-point of entry for the bronchi, vessels, and nerves into each lung
-also an indented region of a lymph node where blood vessels and nerves are attached
Lingula
small portion of the left lung that is the equivalent of the middle lobe in the right lung
Partial pressure of carbon dioxide
measurement of percentage of carbon dioxide in blood
Primary respiratory acidosis
a decrease in blood pH secondary to insufficient exhalation of CO2
Primary respiratory alkalosis
an increase in the blood pH secondary to excessive exhalation of CO2
Surfactant
mixture of lipids and proteins synthesized to reduce the tendency of alveolar collapse and to ease alveolar inflation
Turbinates
a set of bony convulsions formed by the conchae ni the nasopharynx that help to maintain smooth airflow
Vestibular folds
superior portion of the vocal cords, also called the false vocal cords
Heart valves (x4)
-tricuspid
-mitral
-pulmonic
-aortic
Parts of the intrinsic conduction system of the heart
-sinoatrial node
-atrioventricular node
-bundle of His
-bundle branches
-Purkinje fibers
Regulation of heart function involves (x3)
(1) chronotropic effect
-control of heart rate
(2) dromotropic effect
-conductivity
(3) inotropic
-strength of contractions
PQRST
-PR
-QRS (ventricular depolarization)
-ST
-T (ventricular repolarization)
Cardiac output
amount of blood pumped through the circulatory system in one minute
Coronary arteries
-supply heart with blood
-arise from aorta
Pulmonary circulation
carried blood from the right side of the heart to the lungs and back to the left side of the heart
Systemic arterial circulation
carries oxygenated blood from the heart through the AV valve, into the aorta, and out to the body
Circulation to the head and neck involve...
-brachiocephalic artery
-left common carotid artery
-left subclavian atery
Circulation to the upper extremities involves...
-subclavian artery
-vertebral artery
-axillary artery
-brachial, ulnar, and radial arteries
Major abdominal arteries
-celiac trunk
-superior mesenteric artery
-inferior mesenteric artery
Circulation to the pelvis and lower extremities involve...
-aorta
-two common iliac arteries
-internal and external iliac arteries
-femoral arteries
-popliteal arteries
-tibial arteries
-dorsalis pedis arteries
Hepatic portal system
specialized part of venous system that drains blood from the liver, stomach, intestines, and spleen
Erythrocytes
-RBC
-hemoglobin
-contain antigens on surface
Leukocytes
-WBCs
-fight infection by production of antibodies or by directly attacking invaders
Hemostasis
process by which clots are formed and bleeding is stopped
Absolute refractory period
early phase of repolarization in which cell contains such a large concentration of ions that it cannot be stimulated to depolarize
Afterload
pressure in the aorta against which the left ventricle must pump blood
Agranulocytes
leukocytes that lack granules
Albumins
smallest of plasma proteins that make up about 60% of these proteins by weight
Alpha effect
stimulation of alpha receptors that results in vasoconstriction
Anemia
low hemoglobin erythrocyte level
Antigens
substances of molecules that, when taken into the body, stimulate immune system
Automaticity
state in which cardiac cells are at rest, waiting for the generation of spontaneous impulse from within
B cells
lymphocytes that produce and secrete antibodies that bind to and destroy foreign antigens
Cerebellum
part of brain locater dorsal to the pons and is responsible for coordination and balance
Basophils
WBCs that work to produce chemical mediators during an immune response and make up approximately 1% of leukocytes
Beta effect
stimulation fo beta receptors that results in increased inotropic, dromotropic, and chronotropic states
Bilirubin
waste product of RBC destruction that undergoes further metabolism in the liver
Chordae tendineae
thin bands of fibrous tissue that attach to the valves in the heart and prevent them from inverting/prolapsing
Bruit
abnormal whooshing sound indicating turbulent blood flood within a narrowed blood vessel; usually heard in carotid arteries
Bundle of His
portion of electrical conduction system in interventricular septum that conducts the depolarizing impulse from the AV junction to the right and left bundle branches
Circle of Willis
interconnection of the anterior, middle, and posterior cerebral arteries and the anterior communicating artery, which forms an important source of collateral circulation to the brain
Erythroblastosis fetalis
a serious condition that results when a pregnant woman's blood type is incompatible with the fetus' blood type and antibodies from the mother enter the fetal circulation adn destroy fetus' RBCs
erythropoiesis
process of making RBCs
Fibrin
white insoluble protein formed from fibrinogen in the clotting process
Fibrinogen
plasma protein that is important for blood coagulation
Diapedesis
process whereby leukocytes leave blood vessels and move toward tissue where they are needed most
Ejection fraction
percentage of blood that leaves the heart each time it contracts
Hematocrit
percentage of blood volume made up by RBCs
Embolus
a piece of clot that travels from one part of the body to another
Hematopoeisis
process of blood cell production in bone marrow (aka. hemopoiesis)
Heparin
substance found in large amounts in basophils that inhibits blood clotting
Eosinophils
-WBCs with a major role in allergic reactions and bronchoconstriction during an asthma attack
-make up 1-3% of leukocytes
Endocarditis
infection of a heart valve
Neutrophils
-WBCs that are one of three types of granulocytes
-multi-lobed nuclei
-destroy bacteria, antigen-antibody complexes, and foreign matter
Inotropic effect
effect on contractility of muscle tissue
P wave
first wave in ECG complex, representing depolarization of ventricles
Mast cells
-cells to which antibodies attach
-formed in response to allergens
-when allergens on the surface of this, they release potent inflammatory mediators resulting in allergic symptoms or potentially anaphylaxis
Pericardiocentesis
lifesaving procedure to correct a cardiac tamponade, in which a needle is inserted into the pericardial sac to remove excess fluid from the heart
Mesenteric angina
pain caused by partial occlusion of the mesenteric artery from atherosclerosis
Mitral valave
valve in heart that separates left atrium from the left ventricle
Plasmin
clot-dissolving enzyme
SA node
-dominant pacemaker of the heart
-located in the junction of the superior vena cava and right atrium
Pons
-mass of nerve fibers at the end of the medulla oblongata
-portion of brainstem that lies below midbrain
-affect sleep adn respiraton
Sinusoids
part of hepatic portal system in which blood collects within the liver and the liver cells extract nutrients from the blood, filter the blood, and metabolize various drugs
PR segment
-period between atrial depolarization and the onset of ventricular depolarization
-signifies the time required for atrial depolarization and passage of the excitation impulse thru the AV junction
Superior vena cava
-one of the two largest veins in the body
-carried blood from upper extremities, head, neck, and chest into the heart
Raynaud phenomenon
spasms that develop in digital arteries, particularly following emotional stress or cold exposure, resulting in white and cool fingertips
QRS complex
produced byT cells ventricular depolarization
T wave
represents ventricular repolarization
Saphenous vein
-longest vein in body
-drains leg, thigh, and dorsum of the foot
Tricuspid valve
heart valve that separates right atrium from right ventricle
Tunica media
-middle and thickest layer of tissue of a blood vessel wall
-composed of elastic tissue and smooth muscle cells that allow the vessel to expand or contract in response to changes in bp and tissue demand
Lymphatic system
-related to cardiovascular system
-transports excess tissue fluid to bloodstream
-absorbs fats and helps to defend against disease-causing agents
-primary organs are thymus and spleen, along with lymph nodes
;Lymphatic vessels
-carry fluid away from tissues
-prevent tissues from becoming edematous by absorbing excess fluid and returning it to central venous circulation
Three lymphatic organs comprising the tonsils
-palatine
-pharyngeal
-lingual tonsils
Two types of lymph tissue
red and white pulp
Most common chemicals in body that promote inflammation (lymphatic system)
-histamines
-kinin
-complement
-prostaglandins
-leukotrienes
-pyrogens
-interferon
Two types of specific immunity
(1) cellular immune response
-achieved by actions of T lymphocytes or T cells
(2) humoral immune response
Antibodies
-gamma globulin proteins called immunoglobulins
-include: IgM, IgA, IgE, IgD, IgG
Helper T cells
-cells that aid WBCs in carrying out cell-mediated immune functions
-maturation of B cells into plasma cells and memory B cells
-activation of cytotoxic T cells and macrophages
B lymphocytes (B cells)
lymphocytes that exist in the blood and are abundant in the lymph nodes, bone marrow, intestinal lining, and spleen
CD4 antigen
protein found on surface of helper T cells that is adversely affected by exposure to HIV
Lymphadenitis
inflammation of a lymph node caused by infection
Lymphadenopathy
any swelling of the lymph nodes, with or without pain
Lymphangitis
infection that spreads beyond the local area into a lymphatic vessel causing red streaks to run from the infected area proximally
Primary immune response
the activation of B or T cells after they first encounter the antigens for which they are specialized to react
Secondary immune response
appearance of concentrations of antibodies in the blood plasma, usually 5-10 days after exposure to antigens
How many cranial nerves?
12 pairs
Major regions of adult brain (x4)
-cerebrum
-diencephalon
-cerebellum
-brainstem
Cholinergic neuron
neuron that secretes acetylcholine
Adrenergic neuron
neuron that secretes norepinephrine
Limbic system
-made up by portions of cerebrum and diencephalon
-influences mood, emotions, motivation, and sensations of pain and pleasure
Abducens nerve
-cranial nerve (VI)
-lateral movement of eyeball
Accessory nerve
-Cranial nerve (XI)
-provides motor innervation to the muscles of the soft palate and the pharynx and to the sternocleidomastoid and trapezius muscles
Brachial plexus
-C5 to T1
-musculocutaneous, radial, ulnar, median
Cauda equina
nerve roots that extend from the spinal cord at the level of the second lumbar vertebra
Cerebellar peduncles
one of three bands of nerve fibers through which the cerebellum communicates with other regions of the central nervous system
Anterior spinothalamic tracts
ascending fiber tracts that carry info to the brain about light touch, pressure, and tickling/itching sensations
Cerebral cortex
-largest part of brain
-controls higher thought processes
-also called cerebrum
Ascending reticular activating system
several structures located throughout the brainstem that are responsible for maintenance of consciousness
Choroid plexus
-specialized cells within hollow areas in the ventricles of the brain
-produce cerebrospinal fluid
Basal ganglia
-located in cerebrum, diencephalon, and midbrain
-play an important role in coordination of motor movements
beta-blockers
-common cardiac drug
-blocks beta effects, causing decrease in workload of heart by reducing speed of contraction and bp
Curare
agent that blocks transmission of neural motor impulses at neuromuscular junction
Hypothalamus
-most inferior portion of diencephalon
-responsible for control of hr, digestion, sexual development, temp regulation, emotion, hunger, thirst, and regulation of sleep cycle
-stimulates secretion of growth hormone
Diencephalon
-part of brain between brainstem and cerebrum
-includes thalamus and hypothalamus
Longitudinal fissye
separates left and right hemispheres of cerebrum
Epithalamus
-part of diencephalon
-emotions, circadian rhythms, and connecting limbic system with other parts of brain
Facial nerve
-cranial nerve (VII)
-supplies motor activity to all muscles of facial expression, the sense of taste to the anterior 2/3 of the tongue, and cutaneous sensation to the external ear, tongue, and palate
Medulla
-inferior portion of midbrain that serves as conduction pathway for afferent and efferent nerves
-inner portion of adrenal glands
-produces epinephrine and norepinephrine
Optic nerve
-cranial nerve (II)
-transmits visual information to the brain
-only cranial nerve considered to be part of CNS
Parietal lobe
-responsible for reception and evaluation of most sensory info, except smell hearing, and vision
Peripheral nervous system
-31 pairs of spinal nerves and 11 of 12 pairs of cranial nerves
-sensory, motor, and connecting nerves
Nodes of ranvier
regions between individual schwann cells in myelinated neurons, between which action potentials jump
Obturator nerve
-nerve emanating from lumbosacral plexus
-innervate muscles that adduct the thigh and rotate it medially
Oculomotor nerve
-cranial nerve (III)
-motion of eyeballs and upper lid
Proprioception
info about body's position of its parts
Olfactory nerve
-Cranial nerve (I)
-transmits info on smell
Schwann cells
nervous tissue that helps form the myelin sheath around certain neurons
Temporal lobe
plays role in hearing and memory
Thalamus
-part of diencephalon
-processes most sensory input and influences mood and general body movement (especially associated with fear or rage)
Trigeminal nerve
-Cranial nerve (V)
-supplies sensation to scalp, forehead, face, and lower jaw
-innervates muscles of mastication, throat, and inner ear
Vagus nerve
-cranial nerve (X)
-provides motor function to soft palate, pharynx, and larynx
-carries taste bud fibers from the posterior tongue, sensory fibers from the inferior pharynx, larynx, thoracic, and abdominal organs, and parasympathetic fibers to thoracic and abdominal organs.
Substantia nigra
layer of gray matter located in midbrain
Subthalamus
part of diencephalon involved in controlling motor functions
Vestibulocochlear nerve
-cranial nerve (VIII) that passes thru internal auditory meatus
-hearing and balance
12 Cranial nerves
-I Olfactory (Smell)
-II Optic (Sight)
-III Oculomotor (Moves eyelid and eyeball and adjusts the pupil and lens of the eye)
-IV Trochlear (Moves eyeballs)
-V Trigeminal (Facial muscles incl. chewing; Facial sensations)
-VI Abducens (Moves eyeballs)
-VII Facial (Taste, tears, saliva, facial expressions)
-VIII Vestibulocochlear (Auditory)
-IX Glossopharyngeal (Swallowing, saliva, taste)
-X Vagus (Control of PNS e.g. smooth muscles of GI tract)
-XI Accessory (Moving head & shoulders, swallowing)
-XII Hypoglossal (Tongue muscles - speech & swallowing)
Epidermis
-outer layer of skin made up of stratified squamous epithelium
-nerve vessels but no nerve endings
-composed of five layers (stratum corneum, stratum lucidum, stratum granulosum, stratum spinosum, and stratum germinativum)
Stratum corneum
-outer layer of epidermis
-dead cells
Stratum germinaticum
innermost layer of epidermis
Stratum granulosum
-layer of epidermis that sits between stratum lucidum and stratum spinosum
-composed of flattened cells that contain granules of keratohyalin
Four layers of alimentary canal
-mucosa
-submucosa
-adventitia (muscle)
-serosa (outer lining of bowel)
Right upper quadrant contains
-liver
-gallbladder
-part of large intestine
-right kidney
Left upper quadrant contains
-stomach
-spleen
-pancreas
-part of large intestine
-left kidney
Right lower quadrant contains
-appendix
-part of large intestine
-right ovary
-right ureter
-part of uterus
-urinary bladder
Left lower quadrant contains
-part of large intestine
-left ovary
-left ureter
-part of uterus
-urinary bladder
Rugae
thick folds of the stomach wall
What does the lining of the inner stomach mucosa contain?
-contains gastric pits with parietal, chief, and endocrine cells
Spleen
-highly vascular organ
-removal of old blood cells and fighting infection
Pancreas
-elongated organ
-manufacture of digestive enzymes and the hormones insulin and glucagon
Absorptive cells
cells that produce digestive enzymes and absorb digested food
Adventitia
muscular layer of wall of alimentary canal
Alimentary canal is made up by...
mouth, pharynx, esophagus, stomach, small intestine, large intestine, rectum, anus
Ampulla of Vater
opening in the duodenum into which the common bile duct and the pancreatic duct drain
Carboxypeptidase
pancreatic enzyme that digests proteins
duodenojejunal flexure
sharp bend in the small intestine between the duodenum and jejunum
Endocrine cells
cells in stomach mucosa that produce regulatory hormones
Chief cells
cells in stomach mucosa that produce pepsinogen (important enzyme in digestion of food)
Esophageal hiatus
opening in diaphragm through which the esophagus passes
Cholecystitis
-symptoms from cholelithiasis
-aka gallbladder attack
Cholecystokinin
-hormone produces in intestine
-stimulates production of pancreatic secretions
-gallbladder contractions
-inhibits gastric motility
Cholelithiasis
presence of gallstones
Flatus
gas within colon
Chymotrypsin
pancreatic enzyme that digests proteins
Crypts
-tubular glands located in colon
-contain mucus-producing goblet cells
Gastrin
-hormone produced by endocrine cells of stomach
-increases stomach secretions and rate of gastric emptying
Goblet cells
cells that produce a protective mucous lining
Haustra
recesses in colon caused by contraction of the teniae coli
Lipases
pancreatic enzymes that break down fat
Mastication
chewing
Peyer patches
intermittent patches of lymph nodes located in the ileum
Plicae circulates
circular folds that run perpendicular to digestive tract and increase surface area for absorption
McBurney point
anatomic landmark in RLQ that represents the location of pain associated with appendicitis
Secretin
-hormone produced by duodenum
-inhibits gastric secretion and stimulates production of alkaline pancreatic secretions
Trypsin
pancreatic enzyme that aids in digestion of protein
Prostaglandins
-group of hormone-like fatty acids produced in many body tissues
-act on target organs to produce effects such as uterine contraction, regulation of bp, smooth muscle contraction, pain, and imflammation
Hormones
-act by binding to receptors
-corticosteroids and thyroid hormones bind to receptors located within cells
-all other hormones bind to receptors located on surface of cells
Pituitary gland
-master gland; located as base of brain
-secretes hormones that regulate basically F-ing everything
-regulate function of many glands in body
-is regulatED by the hypothalamus
-posterior portion is directly connected to and continuous with the brain (called neurohypophysis... produces neurohormones)
Neurohypophysis
=posterior portion of the pituitary gland that produces hormones called neurohormones
-antidiuretic hormone and oxytocin
Antidiuretic hormone (ADH)
-produced by neurohypophysis (posterior pituitary)
-constricts blood vessels and raises bp
-targets kidneys and promotes retention of water (reduces urine output)
-vasopressin
Oxytocin
-neurohormone produced by neurohypophysis (posterior pituitary)
-contraction and lactation
Anterior pituitary
-aka. adenohypophysis
-hormones produced are not neurohormones because this portion is not considered part of CNS
Adrenocorticotropic hormone (ACTH)
-hormone that targets adrenal cortex to secrete cortisol
-essential for development of cortex of adrenal gland and its secretion of corticosteroids
-stimulated by stress, trauma, major surgery, fever, etc.
Two major hormones produced by the thyroid gland
-triiodothyronine (T3)
-tetraiodothyronine (T4)
-hormones produced in response to stimulation from anterior pituitary by thyroid-stimulating hormone
Parathyroid glands
-located on posterior thyroid gland surface
-produce parathyroid hormone (maintains calcium in blood and normal neuromuscular function)
Three major female hormones
-estrogen
-progesterone
-human chorionic gonadotropin
Pineal gland
secretes melatonin
Acromegaly
-disorder caused by overproduction of growth hormone by pit. gland
-enlargement of flat bones
-aka. gigantism
Addisonian crisis
acute adrenocortical insufficiency
Aldosterone
-one of two main hormones that adjust final composition of urine
-increases rate of active reabsorption of sodium and chloride ions into blood
-decreases reabsorption of potassium
Alpha cells
-cells located in inlet of Langerhans
-secrete glucagon
Beta cells
-cells located in islets of Langerhans
-secrete insulin
Calcitonin
-hormone produced by thyroid
-regulates calcium levels in body
Conn syndrome
-condition resulting in excess secretion of aldosterone
-commonly caused by benign tumour
Cortisol
-corticosteroid secreted by adrenal cortex
-stress hormone
Exophthalmos
protrusion of eyes
Follicle stimulating hormone
-hormone that regulates eggs, sperm, and reproductive hormones
-released from pituitary gland
-helps stimulate oocyte to undergo meiosis
Glucagon
-hormone produced by pancreas
-controls metabolism and blood glucose level
-stimulates breakdown of glycogen to glucose
Gonadotropin-releasing hormone
-hormone released by hypothalamus
-influences release of luteinizing hormone and follicle stimulating hormone
Hyperparathyroidism
-condition resulting in loss of calcium
-caused by excess secretion of parathyroid hormones
Islets of Langerhans
special group of cells in pancreas where insulin and glucagon are produced
Tetany
painful muscle spasms
Three divisions of the adrenal cortex
-zona fasciculata (corticosteroids)
-zona glomerulosa (mineralocorticoids)
-zona reticularis (some weak male sex hormones or androgens)
What structure of the kidney supplies blood to the glomerulus?
the afferent arteriole
Angiotensin II
-form of kinin that plays role in bp maintenance
-causes vasoconstriction and sympathetic activation by stimulating adrenal gland to increase aldosterone
Detrusor muscle
-muscle surrounding neck of bladder to form internal urethral sphincter
-functions in micturition reflex
Diabetes insipidus
-condition caused by pituitary dysfunction
-associated with large production of dilute urine
Distal convoluted tubule
-part of nephron
-empties urine into collection duct then carries it to the calyces
Efferent arteriole
-structure of kidney that drains blood from glomerulus
Glomerular capsule
-sac-like structure that surrounds the glomerulus
-receives filtered fliud
Renal corpuscle
initial blood-filtering component of nephron
Renal medulla
-inner portion of each kidney
-made of conical renal pyramids
-has striations
Juxtaglomerular cells
-cells located in afferent arterioles of glomerulus
-play part in regulating volume statue of body
Loop of Henle
U-shaped portion of renal tubule that extends from the proximal to the distal convoluted tubule
Renal tubule
portion of nephron containing tubular fluid filtered throguh glomerulus
Micturition
urination
Nephrons
-structural and functional units of kidney that form urine
-composed of glomerulus, glomerular capsule, proximal convoluted tubule, loop of henle, distal convoluted tubule
Renin
hormone produced by cells in juxtaglomerular apparatus when bp is low
Renin-angiotensin system
system located in kidney that helps regulate fluid balance and bp
Tubular reabsorpion
process that moves substances from the tubular fluid into the blood within the peritubular capillary
Plasma
-yellow fluid that carries blood cells and nutrients
-transports cellular waste material to organs of excretion
-makes up 55% of total blood volume
Ureter
-thick-walled hollow tubes that carry urine from kidneys to bladder
Proximal convoluted tubule
-part of nephron
-include glomerular capsule
Vasa recta
-series of peritubular capillaries that surround loop of Henle
-water moves here after passing through descending and ascending limbs of loop of Henle
Allele
-variant form of a gene
-can be identical or slightly different in DNA sequence
Amniocentesis
-procedure of extracting amniotic fluid from the uterus using a needle and ultrasound or CT scan
Autosomes
chromosomes that do not carry genes that determine sex
Ejaculatory duct
-structure formed by vasa deferentia and seminal vesicle
-passes through prostate gland to empty into the urethra
Bulbourethral glands
-glands that lie inferior to the prostate gland
-secrete a lubricating fluid that prepares the penis for sexual intercourse
Endometrium
inner layer of uterine wall
Epididymides
-tightly coiled tubes connected to ducts within a testis
-become vas deferens
Corpus cavernosus
erectile tissue found in clitoris and penis
Foramen ovale
opening between two atria that is present in fetus but closs shortly after birth
Gamete
sex cell (sperm and ovaries)
Cremaster muscle
muscle that contracts and pulls the testicles close to the body during cold weather
Dartos muscle
Layer of cutaneous muscle within the scrotum that contracts during cold weather and causes the skin to become firm and wrinkled
Gestation
process of fetal development following fertilization
Gonadotropin-releasing hormone (GnRH)
-hormone released from hypothalamus
-stimulates uterine lining during menstrual cycle
Graafian follicle
mature or developed ovum
Efferent duct
pathway by which spermatozoa leave testes
Myometrium
thick muscular middle layer of uterine all
Oocyte
-precursors to a mature egg
-formed in ovaries
Oogenesis
process of egg cell formation which begins at puberty
Ostium
opening in the infundibulum formed by fallopian tubes
Human chorionic gonadotropin (hCG)
hormone that stimulates the corpus luteum to produce progesterone during the first 8 weeks of gestation
infundibulum
space formed in the peritoneum by the distal end of the fallopian tubes
Perimetrium
serous membrane coating that makes up the outside layer of the uterine wall
Perineum
area between the urethral opening and the anus
Luteinizing hormone (LH)
-hormone released from pituitary gland
-released in monthly intervals that help stimulate one oocyte to undergo meiosis (stimulates ovulation)
Progesterone
hormone released from ovaries that stimulates uterine lining during menstrual cycle
Prostate gland
male sex gland that secretes alkaline viscous ejaculatory fluid
Menarche
1st menstrual period
Prostate-specific antigen (PSA)
blood test used in diagnosis of prostate cancer
Ribonucleic acid (RNA)
-nucleic acid made from DNA in the nucleus of the cell
-move to the cytoplasm where it serves as a template for production of proteins
Seminal vesicles
storage sacs for sperm and seminal fluid which empty into the urethra at the prostate
Seminiferous tubules
-highly coiled structures inside each lobule of a testis
-form network of channels, then ducts, which join the epididymis
Vas deferens
spermatic duct of the testicles
Vestibular gland
-one of two glands that lie on each side of the vaginal opening
-secretes mucus into the vestibule to moisten and lubricate vagina for insertion of penis
Spermatic cord
cord composed of testicular artery, venous plexus, lymph vessels, connective tissue, and cremaster muscle
Spermatogenesis
process by which sperm cells are formed
Zygote
-fertilized egg
-23 chromosomes from each parent
Trophoblast
outer group of cells in a zygote that develop to become the placents
Where does the optic nerve enter the globe?
enters the globe posteriorly through the optic foramen
Retina
-made up of 10 layers of nervous tissue
-receives light impulses that generate nerve signals that are conducted to the brain through the optic nerve
Five primary taste types
-sweetness
-sourness
-saltiness
-bitterness
-umami
Perception of sound
-Sound waves enter the ear through the auricle and travel through external auditory canal to the tympanic membrane
-at the tympanic membrane, vibration against the membrane sets up vibrations in the ossicles
-vibrations of the ossicles are transmitted to the cochlear duct at the oval window
-this causes fluid within the cochlea to vibrate
-these vibrations stimulate hairs at the organ of Corti, which send nerve impulses to the brain via the auditory nerve
Sensation of balance
-consists of static equilibrium and dynamic equilibrium
Anterior chamber (eye)
area between the lens and the cornea that is filled with aqueous humour
Aqueous humour
clear, watery fluid behind the eye (anterior chamber of the globe)
Auricle
-large outside portion of the ear through which sound waves enter the ear
-aka. Pinna
Cochlea
shell-shaped structure within the inner ear that contains the organ of Corti
Cochlear duct
canal within the cochlea that receives vibrations from the ossicles
Conjuctiva
a thin, transparent membrane that covers the sclera and internal surfaces of the eyelids
Cornea
transparent anterior portion of the eye that overlies the iris and pupil
Crista
small elevation in each ear canal
Crista ampullaris
sensory organ in a semicircular canal that aids with dynamic equillibrium
Cupula
cap of gelatinous tissue in the ear that is involved in the sensation of balance and movement
Ear canal
-cavity leading from the exterior atmosphere to the tympanum
-aka. external auditory canal
Eardrum
-thin membrane that separates the middle ear from the inner ear
-transmits vibrations to the ossicles
-aka. tympanic membrane
endolymph
fluid in the membranous labyrinth of the ear
External auditory canal
-area in which sound waves are received from the auricle before they travel to the eardrum
-aka. ear canal
External ear
-contains pinna, ear canal, and exterior portion of the tympanic membrane j
Organ of corti
-organ that is the primary receptor for sound
-made up of thousands of cilia
Otolith
small calcium carbonate stones with gelatinous protein that aid in sensation of motion
Gustation
sense of taste
Hyperesthesia
any of several conditions that result in excess skin sensitivity, especially to touch or cold
Otolithic membrane
membrane within the inner ear that contains otolith and aids in sensation of motion
Oval window
oval opening between the middle ear and the vestible
Pinna
-large outside portion of the ear through which soundwaves enter the ear
-aka the auricle
Inner ear
composed of cochlea and semicircular canals
Iris
-the sphincter muscle and surrounding tissue behind the cornea
-dilate and constrict the pupil
-regulate the amount of light that enters the eye
-pigment in this tissue gives eye its colour
Punctum lacrimale
small opening in the corner of the eye through which tears drain from the lacrimal ducts
Pupil
circular opening in the center of the eye through which light passes to the lens
Sclera
white part of the eye
Macula
specialized patches of tissue within the utricle and saccule that aid in the sensation of motion
Lens
transparent part of the eye through which images are focused on the retina
Taste hairs
hair-like projections of the gustatory cells of the taste buds
Olfactory bulbs
-structures in the forebrain that are needed to perceive odors
-cranial nerve for smell
Olfactory cortex
area in the brain that receives odor impulses and perceives them as smell
Utricle
an enlarged portion of the labyrinth of the inner ear that contains a specialized patch of tissues that aids int he sensation of position and motion
Middle ear
consists of inner portion of the tympanic membrane and the ossicles
visual cortex
area in the brain where signals from the optic nerve are converted into visual images
Vitreous humour
a jelly-like substance found in the posterior compartment of the eye between the lens and the retina
Macronutrients
carbohydrates, lipids, and proteins
Metabolism
sum of all chemical processes that take place in the body, resulting in storage or expenditure of energy
Anabolism
-build up of energy reservoirs and molecules in the body
-constructive component of metabolism
-synthesis of larger molecules from smaller ones
Catabolism
-breakdown of energy in the body
-destructive component of metabolism
-breakdown of larger molecules to smaller ones
Thermoregulation
-under primary control of hypothalamus
-temperature regulation
Thermolysis
normal bodily means of heat dissipation or loss
Body water content of average adult
50-70% of total body weight
Four methods of heat dissipation from body
-radiation
-conduction
-convection
-evaporation
Aerobic metabolism
-biochemical process that occurs in the presence of oxygen and results in production of ATP
-aka. cellular respiration
Anaerobic metabolism
-alternate form of metabolism that occurs when oxygen levels are low and less energy is produced than during aerobic respiration
-lactic acid is produced as a waste product
Basal metabolic rate (BMR)
rate at which nutrients are consumed by body at rest
Calorie
the amount of heat needed to raise the temperature of one gram of water by 1 degree C
Cellular respiraton
-biochemical process resulting in production of energy in the form of ATP
-also called etabolism
Extracellular fluid
-fluid found outside of cell membrane
-contains most of supply of sodium
-15% of body weight
Glycogen
long polymer from which glucose is converted in the liver
Glycolysis
process that involves a series of enzymatically catalyzed reactions in which glucose is broken down to make lactic or pyruvic acid
Hydrolysis
splitting of a molecule by adding water
substrate
target of enzyme action
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