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T-cell mediated immunity

Terms in this set (70)

T cells undergo development in the:
Thymus where they migrate to peripheral lymphoid organs, where they are activated by foreign antigen
Secondary lymphoid tissue
Lymph nodes
Spleen
Peyer's Patch

-Anatomical crossroads for interactions of antigens and lymphocytes
Where do naive T cells encounter antigen?
Naive T cells encounter antigen during their recirculation through secondary lymphoid tissues
6 types of Effector T cells
CD8 cytotoxic T cells
CD4 TH1 cells
CD4 TH2 cells
CD4 TH17 cells
Follicular helper T cells
CD4 regulatory T cells
Cytotoxic T cells
Kill virus infected cells
Th1 cells
Activate infected macrophages, provide help to B cells for antibody production
Th2 cells
Provide help to B cells for antibody production, especially switching to IgE
Th17 cells
Enhance neutrophil response, promote barrier integrity (skin, intestine)
Follicular helper T cells
B cell help, isotype switching, antibody production
Regulatory T cells
Suppress T cell responses
Migration of T cells into secondary lymphoid tissues
...
Where do naive lymphocytes enter the lymph node:
1.) From the afferent lymphatics
2.) From the blood via the HEV
What cytokines do T cells use to enter secondary lymphoid tissue
CCL19
CCL21
CXCL13
CCL19 and CCL21 are secreted by:
Resident stromal and dendritic cells
Function of CCL19 and CCL21
CCL19 and CCL21 attract T cells to the T cell zone of the lymph node
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