29 terms

Picornaviridae

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picornaviridae
-size, shape, envelope, ssRNA
groups
-enteroviruses
-Rhinoviruses
Current picornaviridae taxonomy
Rhinovirus
Enterovirus
Hepatovirus
know this slide?
Picornaviruses, PICO-RNA-virus
-mnemonic
picornaviruses
-polio, serotypes
-natural host
schematic polio
? what to take from this
polio replication cycle
-ssRNA, + polarity
-one large poly protein precursor
-proteolytically cleaved
-RNA dependent RNA polymerase
-replication of viral genome
poliovirus
transmission
poliovirus
pathogenesis
-silent infections
-clinically apparent
poliovirus symptoms
-abortive infection
-non paralytic poliomyelitis/asceptic meningitis
-paralytic poliomyelitis
epidemiology of polio a paradox
-describe
?
viral vaccines
general
-attenuated
-inactivated vaccines
-recombinant vaccines
nucleic acid vaccines
comparison of attenuated vs inactivated vaccines
-immunity duration
-effectiveness
-immunoglobulins
-cell mediated immunity
-reversion to virulence
-stability @ room temperature
-excretion of virus & transmission to nonimmune contacts
?
poliovirus vaccines
-Salk vaccine (IPV)
-Sabin vaccine (OPV)
poliovirus vaccine
-comparison Salk (IPV) vs Sabin OPV
-prevent disease
-induce humoral IgG
-induce intestinal slgA
-prevent intestinal colonisation
-secondary (herd) protection by spread to others
-revert to virulence
-cause disease in immunocompromised
effect of poliovirus vaccines in the USA
-incidence of poliomyelitis 1950-1990
-1979
01991
regimens of poliovirus immunisation used in the USA
-1955-1963,
- 1063- 1999
-1999
-2000- present
-why change the immunisation regiment?
western hemisphere free of endemic polio virus
-1974-2000
-VAPP
-wildtype
-2000-present
1988 global poliovirus eradication initiative launched by WHO
-paralytic polio
-serotype 2
numbers yrs?
polio vaccine eradication efforts
-national & multinational immunisation days
-emergency outbreak respose
Wild poliovirus
-polio virus remains endemic in four countries
-2010 import associated outbreaks
Enteroviruses (including coxsackievirus & echovirus)
-common
-diverse clinical symptoms
-range from minor to severe illness
-linked to other diseases
-millions of infections/yr
enterovirus
-similarities to poliovirus
-transmission
-infection sites
enterovirus
common clinical manifestations of
-herpangina
-hand, foot & mouth disesae (coxsackie A16)
-aseptic meningitis
-myocarditis
Enterovirus
Coxsackie A16 aka Hand foot & mouth disease (HFMD)
-children
-seasonal
-symptoms
Enterovirus
Coxsackie A16 aka Hand foot & mouth disease (HFMD)
-transmission
-direct vs respiratory
-shed of virus
-treatment
Enterovirus
Coxsackie A16 aka Hand foot & mouth disease (HFMD)
-seasonal
Coxsackie A16 aka Hand foot & mouth disease (HFMD)
-age group
Rhinovirus- the common cold
-similarities to polio virus
-serotypes
-transmission
-infected is limited to certain area
Rhinovirus-
causes of the common cold
-rhinovirus
-coronavirus
-other viruses