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Adrenergic Agonists (Lecture 6)
Terms in this set (23)
What is the MOA of β-2 Adrenergic Agonists?
Binds to β-2 receptor, bronchodilator (asthma)
What are the common β-2 Adrenergic Agonists?
What is the MOA of Muscarinic Acetylcholine Antagonist?
Bind to the muscarinic receptors (antagonize M1, M3, & M5) --> Antagonizing stimulation of PLC (to inhibit bronchoconstriction), antagonizing M2 and M4 so you don't get inhibition of adenylate cyclase (stimulate bronchoconstriction
What are the common Muscarinic Acetylcholine Antagonist?
What is the MOA of Methylxanthene?
1. CNS stimulant ); 2. bronchodilator: relaxes smooth muscles in airways through inhibition of cAMP and cGMP PDEs, 3. adenosine agogonist: may stimulate release of catecholamines
What are the common Methylxanthene?
What is the MOA of PDE Inhibitors?
Selectively inhibits PDE-4 in treatment of COPD (mechanism not fully understood)
What is the common PDE Inhibitor?
What is the MOA of Glucocorticoids?
Primary: Anti-inflammatory in epithelia of lung cell
What are the common Glucocorticoids?
What is the MOA of Mast cell stabilizers?
Inhibition of histamine release and other mediators of inflammation, stabilizes mast cells
What is the common Mast cell stabilizer?
What is the MOA of Leukotriene Inhibitors?
Blocks action of leukotriene D4 on cysteinyl leukotriene receptor CystLT1 in the lungs and bronchial tubes
Inhibits 5-lipoxygenase in the eicosanoid synthesis pathway
What are the common Leukotriene Inhibitors?
What is the MOA of Monoclonal Antibody?
Inhibits binding of IgE to IgE receptor FCεRI on the surface of mast cells and basophils (limits degree of release of mediators of the allergic response)
What is the common Monoclonal Antibody?
What medication Stimulates respiratory tract secretions?
What medication is a Centrally acting cough suppressant in the CNS?
What medication Increases blood flow to kidneys without affecting heart rate or BP?
What is the MOA of α-1 Agonist?
Potent vasoconstrictor (less potent than Ep and NorE)
What is the common α-1 Agonist?
What is the MOA of α -1 and β-1 Agonists?
Increases BP, heart contraction and strength
What is the common α -1 and β-1 Agonists?
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