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Osteoporosis Agents (Lecture 20)
Terms in this set (16)
What is the MOA of Bisphosphonates?
Binds hydroxyapatite in bone; innhibits osteoclast binding in bone surface
What are the common Bisphosphonates?
What is Calcitonin used to for?
What is the MOA of Calcitonin?
Acts as antagonist to PTH signaling of osteoclasts --> shutting them down; (high calcitonin, low PTH)
What is Estrogen used for?
Hormone Replacement Therapy
What is the MOA of Estrogen?
Decrease osteoclast recruitment and activity, inhibit PTH peripherally, increase calcitrol, decrease renal calcium excretion, decrease cytokine concentrations
What is Tibolone used for?
Hormone Agonist Therapy
What is the MOA of Tibolone ?
Synthetic steroid, metabolites are weak hormone receptor agonists; relieves hot flashes and increase BMD but have no effect on endometrium
What is the MOA of Phytoestrogens?
Bone estrogen receptor agonist, may have direct effect on osteoblast and osteoclasts
What are the common Phytoestrogens?
What is the MOA of Selective Estrogen Receptor Modulators (SERM)?
Estrogen agonist in bone tissue; estrogen antagonist in breast and uterus
What are the common Selective Estrogen Receptor Modulators (SERM)?
What is the MOA of RANK Ligand (RANKL) Inhibitor?
Antibody bonds RANK and prevents ligand binding at RANK on osteoclast
What is the common RANK Ligand (RANKL) Inhibitor?
What is Teriparatide used for?
Bone Formation Therapy
What is the MOA of Teriparatide?
Contains first 34 aa of human PTH, doses in short periods
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