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120 terms

hema lymph - images only

cells, pathologies, labs, diagnostics
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hematopoiesis
LN system
lymphatic system: map
LN region drainage
face LN
neck LN
breast LN
UE LN
female GU LN
LE LN
peau d'orange
indicates edema due to lymphatic obstruction
normal BM
HSC cells: fat 1:1 (50% cellularity: age-dept)
myeloid:erythroid 3:1
parts: cells, fat, sinusoids
RBC/erythroid maturation
mark: CD1a, 13/14/15, 33/34, 68, 117 c-Kit
granulocyte maturation
1o granules: promyelocytes
2o granules: myelocytes
CML
megakaryocyte + platelet devo
eosinophil
basophil
basophilia: IgE-med allergy, CML
monocyte
MF precursor
erythroblast
15-30% BM cells
7d maturation
reticulocyte
2-3d in circulation
normal ct: 0.5-1.5%
stain: new Methylene blue, Wright stain
mature RBC
leukemoid reaction/ reactive neutrophilia = L-shift
poikilocyte/ SCD
T, NK maturation + markers
B cell maturation + makers
leukemoid reaction/ reactive neutrophilia = L-shift
leukocyte response to i2
cell-surface binding in i2
phagocytosis using FcR
phagocytosis: reactions
follicular hyperplasia v follicular lymphom
follicular hyperplasia: Bcl-2 (-)
follicular lymphoma: Bcl-2 (+), small cleaved LC
blood smear: normal
BM: normal
LN: normal
spleen: normal
note follicles = white pulp
vasculature + surrounding = red pulp
Hb types + Ddx
Hb genes + chains
B-thalassemia
target cell, basophilic stippling, HbA2, HbF
sideroblast
perinuclear mt accum Fe2+: MDS, congen
megaloblastic anemia
hemolysis chart
reticulocytosis
spherocytosis
hereditary, warm autoi2 hemolytic anemia
hereditary spherocytosis
G6PDH deficiency
cold autoi2 hemolytic anemia
schistocytes
macro/microangioPx trauma/hemolytic anemia:
DIC, TTP, thrombosis
acute blood loss anemia
slow drop in Hb, slow recovery RBC mass
MDS
ringed sideroblasts
mickey mouse myelocytes
bilobed neutrophils (not shown)
folic acid/Vit B9 + Vit B12: metabolic activity
synth: purine, pyridine, methionine
Vit B12 functions
also required to convert FA/Vit B9 to active form:
N5-methyltetrahydrofolate -> tetrahydrofolate
Chediak-Higashi syndrome
atypical lymphocytes
viral i2; CD8+, skirting cytoplasm
atypical LC v blast
atypical: skirting cytoplasm, ^chromatin condens
LN architecture: cartoon
reactive lymphadenoPx: compare
sinus histiocytosis
mixed cell LN hyperplasia
toxoplasmosis
myeloid + lymphoid neoplasia: chart
myeloproliferative neoplasms
PCV: BM
PM: 1o myelofibrosis: histo
splenomegaly
PM
ET: essential thrombocytosis
mastocytosis
AML
AML: acute promyelocytic leukemia: M3 t(15;17) PML-RARa
promyelocyte: butterfly nuc
Langerhans histiocytosis
Birbeck granules
coffee-bean nuc
CML: natural course: all ->AML
ALL
CLL/SLL
smudge cells, mature/small LC
CLL/SLL flow cytometry
CD5: usually T cell marker; (+) CD5, 19, sIg
hairy cell leukemia
follicular lymphoma
always consider follicular hyperplasia: Bcl-2(-)
DLBCL: diffuse large B-cell lymphoma
multiple myeloma: diagnostics
multiple myeloma: histo
Burkitt lymphoma
starry sky MF
mantle cell lymphoma
EMZL-MALToma
mycosis fungoides
convoluted nuc
adult T cell leukemia
flower-shaped nuc
anaplastic large cell lymphoma
hallmark cell: horseshoe-shaped
classical HL: Reed-Sternberg cells
bi-lobed nuc, each +huge nucleolus
HL: nodular sclerosing variant
HL: LC depletion variant
HL: mixed cellularity variant
B cell targets for therapy
others: CD52 (CD30 - usually T cell, but expressed in HL)
CTLA-4
PD-1
Rituximab
Brentuximab
Denileukin difitox
Campath/ Alemtuzumab
CLL, CTLC, T-cell lymphoma
chemotherapy targets
cell cycle: chemotherapy targets
hereditary hemorrhagic telangiectasia
Henoch-Schonlein purpura
TTP
hyaline microthrombi: plt only
schistocytes (helmet cell)
heparin-antithrombin III
thrombomodulin-Protein C-Protein S
coagulation cascade downreulation
thrombomodulin-prot C-prot S --| FVIII, FV
heparin-AT III --| FXI, FIX, FX, FVII, FII
PE
PE: CT scans
pseudothrombocytopenia
smear + EDTA -> plt clumping
wet purpura
ITP: BM
antiphospholipid Ab syndrome
HIT: heparin-induced thrombocytopenia
antiplatelet Rx
aspirin
ticlopidine
Abciximab
Warfarin
thrombolytics
ABO groups: terminal saccharides
ABO gels: pt O
crossmatch - mini
blood components