divided into paraxial, intermediate, and lateral sections. gives rise o muscles, bones, blood, CT, dermis, Kidney, ureters, serosa lining, CV, blood, lmphatics, spleen, internal genitalia, adrenal cortex aplastic anemia (NOT aplastic crisis - only RBC, not pancytopenia) due to infection (parvovirus/sickle, EBV), drugs like carbamazepine, chloramphenicol, sulfonamides, exposure to radiation or toxins like benzene, solvents, and autoimmune.
Histo: hypo cellular. fat cells and marrow storm. dry tap.
could also be severe B12 and folic acid deficiency anemia, acute leukemia, MDS.
anticholinergics (first gen antihistamines, GI antispasmodics)
CV: alpha 1 blockers, centrally acting alpha 2 agonists, many antiarrythmics
CNS: Tricyclic antidepressants, antipsychotics, barbiturates, bentos, other hypnotics
Endocrine: long acting sulfonylureas, sliding scale insulin
Pain: non-selective NSAIDS, skeletal muscle relaxants.
ok: low dose thiazide, ACE-I, long acting Ca channel blockers like amlodipine, SSRI
Cimetidine, Ciprofloxacin, Erythromycin (azithromycin doesn't have much effect on p450) Azole antifungals, Grapefruit juice, Isoniazid, Ritonavir (protease inhibitors), ketoconazole, cyclosporine, HIV protease inhibitors, omeprazole, ACUTE alcohol abuse, amiodarone, , quinidine
when using p450 inhibitors, pravastatin is the statin of choice.
contaminated water exposure (hospital, cruise ship, spas, air-conditioned hotels), interstitial pneumonia, 40 degree fever, relative bradycardia, neuro sx like confusion, GI water diarrhea, hyponatremia. culture on BCYE, legionella urine Ag test.