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Step 1 Pharm/Drug Mnemonics
Terms in this set (53)
Geriatric patients lose Phase 1 metabolism first, so they retain Phase 2 metabolism, which includes Glucuronidation, Acetylation and Sulfation.
Geriatric patients have GAS.
"G-protein classes by receptor type. Order = a1, a2, b1, b2, M1, M2, M3, D1, D2, H1, H2, V1, V2"
QISS & QIQ til your SIQ of SQS (super kinky sex).
Gq receptor subtypes: H1, A1, V1, M1, M3
Qutesies HAV 1 M&M
Gi receptor subtypes: M2, a2, D2
Gq = smooth mm contraction; Gs/Gi = smooth mm relaxation
QontraQtion; S-I-t down and relax.
Amphetamine increases NE in 2 ways (decreases reuptake and increases release)
AMPHI = 2. Also, ends with NE.
Vesamicol, prevents ACh packaging into vesicles.
VES = vesicle, COL = choline
Hemicholine blocks Na+/choline cotransporter.
HEMI-choline keeps choline on one side of the cell membrane.
Neostigmine is used for post-op ileus and NMJ de-blockade.
I just got a NEO organ.
Pyridostigmine is a long-acting drug.
The PYRamids took a LONG time to build.
Physostigmine crosses the BBB to treat atropine.
Only a trusted PHYSician should cross the BBB.
ACh poisoning: Diarrhea, Urination, Miosis, Bradycardia, Bronchospasm, Excitation of skeletal mm and CNS, Lacrimation, Sweating, Salivation
Benztropine treats PD.
Park my BENZ.
Ipratroprium treats COPD/Asthma.
I PRAy I can breathe soon!
Glycopyrrolate reduces drooling and airway secretions.
GLYCO... sounds like something found in spit/secretions.
Ritodrine reduces premature contractions.
baby is RIGHT ON TIME with RITODRINE
Clonidine treats malignant HTN and is a sedative.
Calm your body and BP down with the CLOWN. Clownidine.
a-methyldopa treats HTN of pregnancy.
Picture the greek alpha as a little fetus.
Penicillamine is an antidote for both lead and copper.
Copper PENnies and lead PENcils.
CN- antidote is hydroxycobalamin.
Shortest toxin name; long treatment name. Also hydroxyCobalamiN.
Cause Vasospasm: Sumatriptan, Ergot alkaloids, Cocaine
coronary vasospasm takes a SEC.
Cause cutaneous flushing: Vancomycin, Adenosine, Niacin, Ca2+ channel blockers.
VANC causes flushing (picture a red VAN?)
Cause Dilated cardiomyopathy: Doxorubicin, Daunorubicin.
Dilated is caused by D & D.
Cause Torsade de pointes: Chloroquine, Halothane, 1A class anti-arrhythmics, Macrolides, Protease inhibitors, Sotalol
CHAMPS of Torsade de pointes.
Cause Agranulocytosis: Clozapine, Carbamazepine, Colchine, Propylthiouracil, Methimazole, Dapsone
When you think about agranulocytosis, think about the number 3: 3 granulocytes will be lost (basophils, neutrophils, eosinophils). And the drugs are 3 C's, 2 anti-T's, and 1 D. The 2 anti-T's refers to PTU and methimazole being anti-Thyroid drugs used for hyperthyroidism. Agranulocytosis: 3 C's, 2 anti-T's, one D.
Cause Aplastic anemia: NSAIDs, benzene, chloramphenicol
Cells meet ther END with N's, BENZ, and ChloramPHEN.
Causes Hemolysis in G6PD patients: Fava beans, Isoniazid, Nitrofurantoin, Dapsone, Primaquine, Aspirin, Ibuprofen, Naphthalene, Sulfonamides
Patients with drug-induced G6PD hemolysis FIND PAINS.
Causes Cough: ACE inhibitors.
Cover your FACE when you take an ACE.
Causes Pulmonary fibrosis: BLeomycin, Amiodarone, Busulfan.
It's hard to BLAB when you have pulmonary fibrosis.
Causes Acute cholestatic hepatits, jaundice: erythromycin.
Red makes you yellow. (Erythro = red)
Causes focal to massive hepatic necrosis: Halothane, Amanita phalloides mushrooms, Valproic acid, Acetaminophen.
HAV Aman fix your necrotic liver.
Causes Hepatitis: INH
INH is IN your Hep. (your liver).
Causes Pseudomembranous colitis: AMOxicillin, AMPicillin, CLINDAmycin
you'll need AMOP-xicillin and AMOP-cillin to CLINDA mess made by pseudomembranous colitis.
Cause Gynecomastia: Spironolactone, TCA's, Alcohol (chronic), Cimetidine, Ketoconazole, Estrogens, Digitalis
STACKED (how you'll look after these drugs).
LITHium causes hypOthyroidism.
LITHium causes a LI-ttle TH-yroid.
Cause Gout: Cyclosporine, Niacin, Furosemide, Thiazides, Pyrazinamide.
Cause Nagging First Toe Pain.
Cause Photosensitivity: Sulfonamides, Amiodarone, Tetracyclines
SAT for a PHOTO. (Teeth were discolored for the photo...tetracyclines are teratogens that cause discolored teeth).
Cause Myopathies: Fibrates, Niacin, Colchine, Hydroxychloroquine, Interferon-a, Penicillamine, Statins, Glucocorticoids
Fish N CHIPS Give you myopathies.
Cause Stevens-Johnson syndroms: allopurinol, Carbamazipine, Lamotrigine, Ethosuximide, Phenytoin, Phenobarbital, Penicillin, Sulfa drugs.
Stevens and Johnson are allopurinol CLEPPPS!
Cause SLE-like syndrome: Sulfasalazine, Hydralazine, INH, Procainamide, Phenytoin
Wolves on a SHIPP. (Wolves = Lupus).
Cause Tendonitis, rupture, cartilage damage: Fluoroquinolones
Tendons and cartilage hit the FLUOR.
Cause Fanconi's syndrome: Expired tetracycline, heavy metals
Picture a heavy metal band called FANCONI. They really let loose: they're loose on ions (Fanconi syndrome involves failure to reabsorb most ions), they're loose on expiration dates, and they hang loose playing heavy metal all day.
Cause Interstitial nephritis: Furosemide, Antibiotics, NSAIDs
Picture a FAN blowing WBC casts and eosinophils into the urine.
Cause Cinchonism: Quinidine, Quinine
Cause Parkinson-like symptoms: Antipsychotics, Reserpine, Metoclopramide
my ARM is shaking.
Cause Seizures: Isoniazid, Bupropion, Imipenem/cilastatin, Tramadol, Enflurane, Metoclopramide
With seizures, I BITE My tongue.
Cause Anti-muscarinic effects: TCAs, H1 blockers, Atropine, Neuroleptics
peeing/tearing/drooling less THAN I was before.
Cause Disulfiram-like reaction (hangover): 1st-generation sulfonylureas, Certain Cephalosporins, Procarbazine, Metronidazole
even if you drink just "1 CC in the PM," you'll still end up with a hangover.
Cause Ototoxicity: Cisplatin, Loop diuretics, Aminoglycosides, Vancomycin
CLAVes hurt my ears.
p450 Inducers (+) = Carbamazepine, Griseofulvin, Phenytoin, Barbiturates, Rifampin, St. John's Wart, Chronic alcoholism
Corona, Guinness, and PBRS INDUCE Chronic alcoholism
p450 Inhibitors (-) = Ciprofloxacin, Ritonavir, Amiodarone, Cimetidine, Ketoconazole, Acute alcohol abuse, Macrolides, INH, Grapefruit juice, Omeprazole, Sulfonamides, Gemfibrozil, Quinidine.
CRACK AMIGOS in GQ (crack is a negative thing that should be INHIBITED.)
Sulfa drugs = Probenecid, Furosemide, Acetazolamide, Celecoxib, Thiazides, Sulfonamide antibiotics, Sulfasalazine, Sulfonylureas
The sulfa drugs are Popular FACTSSS.
Cause methemaglobinemia: Metoclopromide, Anti-malarials (chloroquine/primaquine), Nitrates/nitrites, Sulfonamides, Local anesthetics, Dapsone
Methemaglobin is a MANS LaD.
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