Destruction of inhibition of red bone marrow (drug SE/chemicals/virus)
Autoimmune disorder in elderly (deficiency of vitamin B12)
-Absent or faulty globin chain in Mediterranean ancestry. -RBCs are thin, delicate, and deficient in Hgb
-Defective gene codes for abnormal hemoglobin (HbS) -Causes RBCs to become sickle shaped in low-oxygen situations, clogging small vessels, and causing CP and bone pain. -More common in African Americans
Excess of RBCs that increase blood viscosity (which impairs circulation)
Normal WBC count
What is the most abundant leukocyte?
What do neutrophils do?
-Neutrophils -Eosinophils -Basophils (cytoplasmic granules take up dye/loped nuclei)
Polymorphonuclear leukocytes (PMNs)
What do eosinophils do?
-Digest parasitic worms. -Elevated in allergies
Contain histamine (an inflammatory chemicle that acts as a vasodilator and attracts other WTCs to inflamed sites.)
Lymphocytes and monocytes (lack visible cytoplasmic granules/Spherical or kidney shaped nuclei)
Act against virus-infected cells and tumor cells
Give rise to plasma cells, which produce antibodies.
-Leaves circulation, enters tissue, and differentiates into macrophages. -Activates lymphocytes to mount an immune response. -The largest leukocyte
Production of WBCs
Abnormally low WBC count (drug induced-chemo)
Acute leukemia (AML)
-Involves blast-type cells -Primarily affects children
Chronic leukemia (CLL)
More prevalent in elderly
S & S of leukemia
-Fever -Wt loss -Anemia -Bleeding -Death (internal hemmorhage and overwhelming infections)
-Form a temporary plug that seals breaks in blood vessels. -Small fragments of megakaryocytes -Formation is regulated by thrombopoietin