First Aid - Psych Drugs
Terms in this set (79)
Name three tricyclic antidepressants
What is MOA of TCAs?
Inhibit REUPTAKE of NE and 5-HT at neuronal synapses.
What are side effects of TCAs?
Antismuscarinic effects (dry mouth, etc.)
Name three Monoamine Oxidase Inhibitors.
What is MOA of MAOIs?
Inhibit DEGRADATION of NE and 5-HT at neuronal synapse
Name three SSRIs.
What is MOA of SSRIs?
Inhibit REUPTAKE of 5-HT at neuronal synapses.
What are side effects of MOAIs?
-Hypertensive episodes with ingestion of thyamine-containing foods
What are side effects of SSRIs?
-Inhibits liver enzymes
Name two antipsychotics used to treat ACUTE mania. Extrapyramidal effects are more common with use of these.
Used to treat bipolar disorder, inhibits regeneration of IP3 and DAG. Targeted receptors are unclear, low therapeutic index.
Second line agent used for refractory schizophrenia; small chance of agranulocytosis; weekly blood counts for patients on this agent.
Intoxication with alcohol presents how?
AST 2x > ALT
How do you treat alcohol intoxication?
What are symptoms of alcohol withdrawal?
Mild: Anxiety, tremors, insomnia
Severe: Delirium Tremens (treatment for DTs is benzos)
Intoxication with Opioids presents how?
How do you treat Opioid overdose?
What are symptoms of opiod withdrawal?
What are signs of barbituate intoxication?
Marked respiratory depression
What are symptoms of barbituate withdrawal?
Life threatening cardiovascular collapse
What are symptoms of benzodiazepine intoxication?
Minor respiratory depression
How do you treat benzo intoxication?
Flumazenil (competitive GABA antagonist)
What are symptoms of amphetamine intoxication?
Prolonged wakefulness and attention
What are symptoms of amphetamine withdrawal?
What are symptoms of cocaine intoxication?
Hallucination (inc. tactile)
Angina/sudden cardiac death
How do you treat cocaine intoxication?
What are symptoms of cocaine withdrawal?
Severe psychological craving
Life threatening alcohol withdrawal syndrome that peaks 2-5 hours after last drink. Sxs in order of appearance: Autonomic symptom hyperactivity, psychotic symptoms, confusion
Name class of drugs used to treat alcohol withdrawal
Name class of drugs used to treat anorexia/bulimia
Name drugs used to treat anxiety.
Name drugs used to treat ADHD
What drugs treat atypical depression?
What drugs treat bipolar disorder?
What drugs treat depression?
What drug treats depression with insomnia?
What drugs treat obsessive compulsive disorder?
What drugs treat panic disorder?
What drugs treat PTSD?
What drugs treat schizophrenia?
What's drug of choice to treat Tourette's?
What drugs treat social phobias?
Name 5 antipsychotic drugs
(Haloperidol + 'azines')
What is MOA of typical antipsychotics?
Block D2 receptors= increase in cAMP
What are clinical uses of antipsychotics?
Schizophrenia (primary + symptoms)
What is toxicity of antipsychotics?
-High lipid solubility (stored in body fat) so slow removal from body
-Hyperprolactinemia = galactorrhea
-Antimuscarnic effects (dry mouth, constipation)
What is neuroleptic malignant syndrome? How do you treat it?
Rigidity of muscles
Treatment: Dantrolene, Bromocriptine
What is tardive dyskinesia?
Stereotypic oral-facial movements due to long term antipsychotic use. Often reversible
Name 6 ATYPICAL antipsychotics
"It's atypical for old closets to quietly risper from A to Z"
What is MOA of Atypical Antipsychotics?
Block 5-HT2, dopa, alpha and H1 receptors
What is clinical use of Atypical Antipsychotics?
Schizophrenia (both + and - symptoms)
What is Olanzapine used to treat?
3. Anxiety disorder
What is adverse effect of Clozapine?
May cause agranulocytois (requires weekly WBC monitoring)
"Watch Clozapine Clozely!"
Describe Lithium toxicity
Tremor, sedation, edema, heart block, hypothyroidism, polyuria (ADH antagonist).
Narrow therapeutic window.
What is MOA of Buspirone?
Stimulates 5-HT1A receptors
What is Buspirone used for clinically?
Generalized anxiety disorder
"I'm always anxious if the BUS will be ON time, so I take BUSpirONe.
Name 7 TCAs
What is MOA of TCAs?
Block reuptake of NE and serotonin
What are TCA's used for clinically?
Major depression disorder
What are adverse effects of TCAs?
Alpha blocking effects
What class of TCAs have more anticholinergic effects?
Tertiary TCA's like amitriptyline have more anticholinergic effects than secondary TCA's like nortriptyline.
What are toxicities of TCAs?
Also: respiratory depression, hyperpyrexia
Name 4 SSRIs
What are adverse effects of SSRIs?
How long does it take for antidepressants to take effect?
About 2-4 weeks
What is Serotonin Syndrome?
Caused by any drug that increases serotonin (MAOis)
How do you treat Serotonin Syndrome
-Use Cyproheptadine (5-HT2 receptor antagonist)
Name two SNRIs
What is Venlafaxine used to treat?
2. Generalized anxiety disorder
What are adverse effects of SNRIs?
Name 4 MAOis. Which one is selective MAO-B inhibitor?
4. Selegiline (MAO-Bi)
What is MOA of MAOi's?
Inhibits MAO enzyme which leads to increased levels of amine neurotransmitters (NE, serotonin, dopa)
What are clinical uses of MAOis?
Name 4 atypical antidepressants
What is Bupropion used for?
What is MOA of Bupropion.
Increases NE and Dopa via unknown mechanism. No sexual side effects.
What is MOA of Mirtazapine?
Alpha 2 antagonist (increases release of NE and serotonin)
Also potent 5-HT2 and 5-HT3 receptor antagonist
What is Maprotiline MOA?
Blocks NE reuptake
What is MOA of Trazodone?
Inhibits Serotonin reuptake.
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