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Activation of peripheral receptor results in a generator potential
Graded response, Sums to reach threshold and fire an action potential, Conversion of peripheral stimuli (mechanical or heat) to electrical current
Mechanoreceptors (encapsulated) types
Slowly adapting (SA) - I, Slowly adapting (SA) - II, Fast adapting (FA) - I, Fast adapting (FA) - II
Aδ- mechanonociceptors, C polymodal nociceptors, Silent (sleeping) nociceptors
Defining characteristic of nociceptors
they sensitize, this is unique to nociceptors and means that the rate of firing increases after injury
Do not respond to noxious mechanical/thermal stimuli before injury, After tissue injury, begin to respond to mechanical/thermal stimuli
Touch-pressure receptor, spinal termination, major ascending pathway
SA I receptor, hair follicle, Lamina III-IV, Dorsal columns
Flutter-vibration receptor, spinal termination, major ascending pathway
FA I receptor, FA II, hair follicle, Lamina III-IV, Dorsal columns
Proprioception receptor, spinal termination, major ascending pathway
Muscle spindle, Golgi Tendon, Type II join, Lamina IV-VII, X, Dorsal columns
Cold receptor, spinal termination, major ascending pathway
Aδ and C receptors, Lamina I, II, V, STT*
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