What are the ultrastructural (EM) changes of acute cell swelling?
*Cell swelling with dilation of endoplasmic reticulum (ER)
*Detachment of ribosomes from the rough ER, dissociation of polysomes
*Loss of surface structures (such as microvilli and cilia)
*Breakdown of inter-cellular attachments
*Membrane blebs, myelin figures
*Mitochondrial changes: low-amplitude swelling and early high-amplitude swelling, loss of dense matrix granules, loss of sequestered Ca ions, possible deposition of calcium salts