Only $2.99/month

Pathophysiology Porths ch. 8 Neoplasia

Terms in this set (28)

1) anaplasia: the loss of cell differentiation in cancerous tissue
2) pleomorphism: variations in the size and shape of cells
3) genetic instability: considered to be a hallmark of cancer; high frequency of uncorrected mutations in cancer cells
4) growth factor independence: the ability to proliferate even in the absence of growth factors
5) cell density- dependent inhibition: tend to grow rampantly w/o regard for adjacent tissue
6) low cell cohesiveness and adhesion: reduce tendency of cancer cells to stick together; permits shedding of the tumor's surface cells
7) low anchorage dependence: remain viable and multiply w/o normal attachments to other cells and the extracellular matrix; survive in micro-environments different from those normal cells
8) impaired cell-to-cell communication; interfere w/formation of intracellular connections and responsiveness to membrane-derived signals
9) unlimited life span: divide an infinite number of times, hence achieving immortality
10) antigen expression: express a number of cell surface antigens that are immunologically identified as foreign; tumor antigens can be clinically useful as markers to indicate the presence, recurrence, or progressive growth of cancer
11) cytoskeletal changes: changes in actin filaments and microtubules that facilitate invasion and metastatis
12) substance production; may produce substances that normal cells of the tissue of origin either do not produce or secrete in lesser amounts; may also secrete degradative enzymes that enable invasion and metastatic spread; may also assume hormone synthesis or production and secretion of procoagulant substances that affect clotting mechanisms