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Biology 111: Chapter 1

An Introduction to Biology
STUDY
PLAY
Characteristics of Life (7)
1. Cells & organization
2. Energy use & metabolism
3. Irritability
4. Homeostasis
5. Growth & development
6. Reproduction
7. Biological evolution
Mechanisms of Evolutionary Change (2)
1. Vertical descent with modification
2. Horizontal gene transfer
Taxonomy
Grouping of species based on common ancestry
3 Domains
1. Bacteria
2. Archaebacteria
3. Eukarya
Bacteria
Domain of unicellular prokaryotes that have cell walls.
Archaea
Domain of unicellular prokaryotes that have cell walls.
Eukarya
Domain of all organisms whose cells have nuclei, including protists, plants, fungi, and animals
Eukarya Kingdoms (4)
1. Protists
2. Fungi
3. Plantae
4. Animalia
Energy
Capacity to cause change
Prokarya
Domain of all anucleated organisms with cell walls, including archaea and bacteria.
Development
Change in characteristics of cells and / or certain genes/signaling
Gene
A segment of DNA that is involved in producing a protein.

We have 25,000 functional genes and over 3 billion nucleotides.
Transcription
The process whereby the DNA sequence in a gene is copied into mRNA.
Translation
The process whereby genetic information coded in messenger RNA directs the formation of a specific protein at a ribosome in the cytoplasm.
Genome
The complete genetic makeup of an organism, carries information to make its proteome
Proteome
The complete complement of proteins that a cell or organism can make
Cell
The basic structural and functional unit of all organisms.
Energy Use
To maintain their internal order, ________ is needed by organisms.
Irritability
An organism's ability to respond to environmental stimuli. E.g., kingdom animalia has high ___________.
Cell Theory
All living organisms are composed of cells. They may be unicellular or multicellular. The cell is the basic unit of life. Cells arise from pre-existing cells.
Matter
Anything that has mass and occupies space.
Atom
The smallest unit of an element that retains the properties of the element that cannot be broken down naturally
Properties of Life
Organization of Life
Continuity of Life
Unity
Diversity
Organization of Life
growth & development is possible through the organization of life
Continuity of Life
heredity is possible through the continuity of life (DNA)
Diversity
Many types of environments with diverse organisms=speciation
Unity
Common traits rooted in biological evolution.
Homologous Organs
Organs or body parts that are similar in structure and origin but have different uses in different animals
Analogous Organs
Same function different structure
Vertical Descent with Modification
Progression of changes in a lineage; new species evolve from pre-existing species by the accumulation of mutations that are selected for by natural selection.
Horizontal Gene Transfer
The transfer of genes between cells of the same generation. E.g., penicillin resistant bacteria confers it's immunity to other bacteria.
Human Taxon
eukarya, animalia, chordata-vertebrata, mammalia, primates, haminidae, homo, sapiens
Science
The observation, identification, experimental investigation, and theoretical explanation of natural phenomena.
Theory
Broad explanation of some aspect of the natural world that is substantiated by a large body of evidence. Allows us to make many predictions. Also can never be proved true
Deductive Reasoning
General principles are used to predict specific results. E.g., the pecies of an organism can be deduced from its characteristics
Inductive Reasoning
Specific observations are used to construct general scientific principles.
Scientific Method
A series of steps followed to solve problems
1. Collect data
2. Form a hypothesis
3. Test the hypothesis
4. Analyze data
5. State conclusions
Cystic Fibrosis
Affects about 1 in every 3,500 Americans.
Characterized by thick mucus in the lungs.
Homozygous allele (need 2 bad copies)
Missing amino acid (1 in 1700) prevents ATP from properly binding to protein to pump Cl- ions out of the cell.
Dorothy Anderson found it to be a genetic disorder; Tsui, Collins, & Riordan identified CF gene.
Biosphere
All the parts of the planet that are inhabited by living things; sum of all Earth's ecosystems.
Ecosystem
A biological community of organisms and their abiotic environment (temperature, sunlight, pH, etc.).
Community
All of the populations (of separate species) living in the same geographical area but NOT producing.

Ex. Wake Tech community consists of student population, cardinal population, crow population, etc.
Population
A group of organisms of the same species populating and REPRODUCING in a given area.
Organism (Species)
Each individual is a group of organ systems cooperating together for a common purpose.
Organ System
Organs cooperating together for a common purpose.
Organ
Tissues cooperating together for a common purpose.
Tissue
Cells cooperating together for a common purpose.
Cell
A _____ is the lowest level of biological organization to have characteristics of life.
Organelle
Subpart of a cell that performs a particular function - e.g., mitochondrion.
Macromolecule
Monomer's bonded together
Molecule
2 or more atoms bonded together (actual monomers are many more than 2)
Atom
Smallest unit of each element that retains that element's characteristics.
Subatomic Particles
Protons, neutrons and electrons.
Biome
A large, naturally occurring community of flora and fauna in a major habitat. E.g., Raleigh is an eastern temperate deciduous forest.
Divergent Evolution
We are united by an evolutionary past. All stem from a limited # of single-celled organisms - life began on earth as primitive cells 3.5-4 billion years ago.
Origin of Life
3.8 Billion Years Ago
Solar System
4.5 Billion Years Ago
Dinosaurs Became Extinct
65 Million Years Ago
Evolution
ANY change in the average characteristics of a population over time.

Does not create new things; gives old things new uses (homologous structures). E.g., Milk Carton birdhouse.
Central Dogma
The information contained in DNA is expressed through the production of mRNA via transcription and the synthesis of proteins via translation of mRNA
Central Dogma
DNA →(transcription)→ mRNA →(translation)→ Protein.
Mutation
Any change in the sequence of the nucleotide bases in the DNA of an individual. Random changes in the genetic material of organisms.
Mutation / Central Dogma
A change in the sequence of nucleotide bases in the DNA will result in a change in the sequence of the nucleotide bases in the mRNA and this may lead to a change in the sequence of the amino acids in the protein. This new sequence of amino acids in the protein could affect its function either positively or negatively.
Vertical Evolution
New species evolve from pre-existing species by the accumulation of mutations, which are random changes in the genetic material of organisms.
Natural Selection
Mutations that alter the traits of an organism such that their chances of surviving and reproducing are increased.

When a mutation causes a beneficial change, frequency of the mutation may increase in a population from one generation to the next.
Charles Darwin
Origin of the Species. Natural Selection
Carolus Linnaeus
Swedish botanist who invented the taxon classification system in the late 1700s.
Vertical Descent with Mutation
Vertical Descent refers to reproduction: parents → offspring → parents → offspring
Mutation: any change in the sequence of DNA nucleotides.
Monomer
Two or more molecules bonded together.
Polymer
Many monomers bonded together.
Mass
A measure (in grams) of the amount of matter an object contains.
Volume
A measure of the amount of space an object occupies.
Example: VD w/ Mod
Over North America, where much of horse evolution occurred, large areas changed from dense forests to grasslands. The horses' increase in size allowed them to escape predators and travel great distances in search of food.
The changes seen in horses' teeth are consistent with a dietary shift from eating more tender leaves to eating grasses and other vegetation that are more abrasive and require more chewing.
Domain Bacteria
Mostly unicellular prokaryotes that inhabit many diverse environments on Earth.
Domain Archaea
Unicellular prokaryotes that often live in extreme environments, such as hot springs.
Kingdom Animalia
Multicellular organisms that usually have a nervous system and are capable of locomotion. They must eat other organisms or the products of other organisms.
Kingdom Fungi
Unicellular and multicellular organisms that have a cell wall but cannot carry out photosynthesis. Fungi usually survive on decaying organic material.
Kingdom Plantae
Multicellular organisms that carry out photosynthesis.
Kingdom Protista
Unicellular and small multicellular organisms that are now subdivided into seven broad groups based on their evolutionary relationships.
GFP
Jellyfish makes green fluorescent protein (GFP). GFP gene is found in the genome of the jellyfish, but the green fluorescent protein is expressed only in the proteome of only certain cells.

With the aid of GFP, researchers can "see"
where genes are expressed in a multicellular organism and where in a cell a particular protein is located.
Hypothesis (Long)
A proposed explanation for a natural phenomenon based on previous observations or studies. Requires work by researchers to evaluate its validity.
Makes testable predictions
Falsifiable - can be shown to be incorrect by additional observations or experimentation.
A hypothesis is never really proven but rather always remains provisional.
Researchers accept the possibility that perhaps they have not yet conceived of the correct hypothesis. After many experiments, biologists may conclude that their hypothesis is consistent with known data, but they should never say the hypothesis is proven.
Hypothesis
A proposed idea.
Theory
A broad explanation backed by extensive evidence.
Theory (Long)
A broad explanation of some aspect of the natural world substantiated by a large body of evidence. Biological theories incorporate observations, hypothesis testing, and the laws of other disciplines such as chemistry and physics.
Cannot be proven true.
E.g., theory that DNA is the genetic material and that it is organized into units called genes.