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Anti Arrythmias

Terms in this set (38)

we have both ___ & __ invervation in the SA & AV nodes
SYmp
Parasymp
The ventricle has ___ innervation
sympathetic
(NO PARA)
FAST response action potential occurs in___
Atria
Ventricle
HIS perkunje
Fast response action potential
phase-0
phase-2
phase-3
phase 0 - Na IN - depolarization
phase 2 - plateu - Ca influx depol
phase 3 - Ka OUT - Repol - refractory phase
which phase of fast response action potential determines CONDUCTION VELOCITY?
phase 0 - Na
more SHALLOW slope of phase 0 means what?
slower depol. / conduction velocity
if you block Na channel of fast action potential what happens?
slower conduction velocity / electrical impulse
what happens if u block K channels in stage 3 on fast action potential?
prolong repol.
phase 0 in a slow action potential in an SA or AV node is mediated by which ion?
Ca influx
which type of action potential can spontaneously depolarize/ automatic?
SLOW. SA & AV
what alters rate at which slow action potential depolarizes?
Symp = reaches threshold quicker
Parasymp= reaches threshold for another action potential slower
what could stop an AV nodal re-entry pathway?
Ca channel blocker
what could stop an atrial or ventricular re-entry pathway/fibrillation?
Na channel blocker (decr. depol)
K channel blocker (prolong repol)
which drug would u give for SINUS BRADYCARDIA?
atropine (muscarinic blocker)
which drug would u give for an AV re-entry tachycardia?
Ca channel blocker
what are the 3 Na channel blockers for fast acting potentials?
Quinidine
Lidocaine
Flecainide
which Na channel blocker can also block K channels?
Quinidine
all Na channel blockers ( quinidine, lido & flecainide) can all decr____
AUTOMATICITY
what happens when you give TOO HIGH of a dose of an anti-arrythmic drug such as a Na channel blocker?
they become PRO-ARRYTHMIC
(instead of anti)
why?- b/c too high dose will block all cells in heart and then some ectopic cells start automatically deporalize=arrythmia
quinidine can be used for which parts of heart?
atria & ventricle arrythmia
lidocaine ONLY works on__
VENTRICLE
someone with a heart attack/ MI. if they have arrythmia, which drug would u use? good for suppressing arrythmias associated with with arrythmia in a MI/ ventricular association?
LIDOCAINE
(lido is weakest and when u have someone with MI which affects the ventricle then u want to be careful so u use lido)
flecainide
strongest Na channel blocker
Not as selective... easy to push dose.
used: to suppress arrythmias in ATRIUM as long as u have NORMAL VENTRICULAR FUNCTION.
side effects on QUINIDINE?
pro arrythmic
ringing in ears = tinitus
hypotension
tachycardia
lidocaine side effects
agitation
convulsions
side effect of flecainide
PRO ARRYTHMIC
which drug can act on the AV node to slow down conduction from atria to ventricle to prevent it from going there?
BETA BLOCKER

(it just protects the ventricle by slowing conduction in AV node)
- used for POST MI PATIENTS
Amiodorone
K channel blocker
incr. refractory period
ALSO.... black Na CHANNELS!!!
amiodorone effects which part of heart?
ATRIA & VENTRICLE
MAJOR side effect of AMIODORONE?
PULMONARY FIBROSIS

why?-long half life.
ca channel blockers dont affect the __ arrythmia. you use them to protect the ___
atria
ventricle
which 2 calcium channel blockers would u use for arrythmias?
Verapimil
DIltiazim
why would u not use Nifdipine as a Ca channel blocker for cardiac arrythmia?
B/c it only dilates smooth muscle and has no affect on heart. so it would dilate so much that we have reflex symp! this would make arrythmia worse!!
Digoxin as anti-arrythmia
PARASYMP activity.
for ATRIAL TACHY
(slows conduction thru AV node)
which 3 drugs can slow AV conduction & protect the ventricle?
DIGOXIN
BETA BLOCKER
Ca CHANNEL BLOCKER
(B-C-D)
Adenosine
slows conduction in AV node.
SHORT HALFWAY
used for: AV re-entry
via IV. used in ACUTE SITUATION.
which Ca channel blocker do u not want for an ARRYTHMIA?
Nifidipine
WHich Ca channel blocker would u not want for ANGINA?
DIltiazim
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