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Terms in this set (38)
we have both ___ & __ invervation in the SA & AV nodes
The ventricle has ___ innervation
FAST response action potential occurs in___
Fast response action potential
phase 0 - Na IN - depolarization
phase 2 - plateu - Ca influx depol
phase 3 - Ka OUT - Repol - refractory phase
which phase of fast response action potential determines CONDUCTION VELOCITY?
phase 0 - Na
more SHALLOW slope of phase 0 means what?
slower depol. / conduction velocity
if you block Na channel of fast action potential what happens?
slower conduction velocity / electrical impulse
what happens if u block K channels in stage 3 on fast action potential?
phase 0 in a slow action potential in an SA or AV node is mediated by which ion?
which type of action potential can spontaneously depolarize/ automatic?
SLOW. SA & AV
what alters rate at which slow action potential depolarizes?
Symp = reaches threshold quicker
Parasymp= reaches threshold for another action potential slower
what could stop an AV nodal re-entry pathway?
Ca channel blocker
what could stop an atrial or ventricular re-entry pathway/fibrillation?
Na channel blocker (decr. depol)
K channel blocker (prolong repol)
which drug would u give for SINUS BRADYCARDIA?
atropine (muscarinic blocker)
which drug would u give for an AV re-entry tachycardia?
Ca channel blocker
what are the 3 Na channel blockers for fast acting potentials?
which Na channel blocker can also block K channels?
all Na channel blockers ( quinidine, lido & flecainide) can all decr____
what happens when you give TOO HIGH of a dose of an anti-arrythmic drug such as a Na channel blocker?
they become PRO-ARRYTHMIC
(instead of anti)
why?- b/c too high dose will block all cells in heart and then some ectopic cells start automatically deporalize=arrythmia
quinidine can be used for which parts of heart?
atria & ventricle arrythmia
lidocaine ONLY works on__
someone with a heart attack/ MI. if they have arrythmia, which drug would u use? good for suppressing arrythmias associated with with arrythmia in a MI/ ventricular association?
(lido is weakest and when u have someone with MI which affects the ventricle then u want to be careful so u use lido)
strongest Na channel blocker
Not as selective... easy to push dose.
used: to suppress arrythmias in ATRIUM as long as u have NORMAL VENTRICULAR FUNCTION.
side effects on QUINIDINE?
ringing in ears = tinitus
lidocaine side effects
side effect of flecainide
which drug can act on the AV node to slow down conduction from atria to ventricle to prevent it from going there?
(it just protects the ventricle by slowing conduction in AV node)
- used for POST MI PATIENTS
K channel blocker
incr. refractory period
ALSO.... black Na CHANNELS!!!
amiodorone effects which part of heart?
ATRIA & VENTRICLE
MAJOR side effect of AMIODORONE?
why?-long half life.
ca channel blockers dont affect the __ arrythmia. you use them to protect the ___
which 2 calcium channel blockers would u use for arrythmias?
why would u not use Nifdipine as a Ca channel blocker for cardiac arrythmia?
B/c it only dilates smooth muscle and has no affect on heart. so it would dilate so much that we have reflex symp! this would make arrythmia worse!!
Digoxin as anti-arrythmia
for ATRIAL TACHY
(slows conduction thru AV node)
which 3 drugs can slow AV conduction & protect the ventricle?
Ca CHANNEL BLOCKER
slows conduction in AV node.
used for: AV re-entry
via IV. used in ACUTE SITUATION.
which Ca channel blocker do u not want for an ARRYTHMIA?
WHich Ca channel blocker would u not want for ANGINA?
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