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a day in the life of a peptide hormone
synthesized in ER, transferred to Golgi, packaged in secretory vesicles... secretion!
premature form of protein hormone that is proteolytically clipped to generate mature form
hormone stored in cell and released in "bursts" when stimulated; allows large amount to be secreted in short time period
hormones secreted as they are synthesized (less common than regulated secretion)
1st and rate-limiting step of steroid synthesis
cholesterol -----> pregnenolone (formed in the inner membrane of peanut, shuttled back and forth between mitochondria and ER for enzyme stuff)
life after secretion (steroids)
btw, rapidly secreted with little storage; bind to plasma proteins usu. low affinity and nonspecific; specific binding proteins affect halflife and rate of elimination
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