Upgrade to remove ads
Biochemical Basis of Disease: Mycosis Fungiodes in a Patient with Ankylosing Spondylitis During Infliximab Therapy
Terms in this set (11)
a chronic inflammatory joint disease that may lead to extra-articular complications
a TNF-alpha antagonist immunosuppressant
When is Infliximab used?
on a severely ill patient whose standard treatment has failed
What is the main effect of this treatment?
Cancer. Cutaneous T cell lymphoma (CTCL)
What can chronic inflammatory autoimmune conditions be associated with?
an increased occurrence of malignant lymphomas
In RA, why does the overall risk of lymphoma double?
attributed to either to the persistent inflammatory disease activity or antirheumatic treatments, such as alkylating drugs MTX and azathioprine as possible tumor promoters although evidence is conflicting
True or False: Patients with AS do not show an increased risk of lymphoma
What do the majority of post-transplant lymphomas appear to be related etiologically to?
EBV (Epstein Barr virus)
How could EBV cause post-transplant lymphomas?
Lymphocytes infected with the EBV proliferate unchecked due to impaired cell mediated immunity
Why would TNF-alpha antagonist treatment possible cause development of cancer?
TNF-alpha and IL1 have a documented tumor reducing capacity. Treatment with anti-TNF drugs, such as infliximab, might thus theoretically promote formation of tumors.
What resulted from blockade of TNF-alpha
Facilitated growth of lymphoma cells by inhibition of apoptotic pathways. Also strongly inhibits cell mediated immunity particularly by inhibiting type 1 cytokine production including TNF-alpha and interferon-gamma. Blockade of TNF-alpha may have suppressed the type I cytokine-mediated inhibition of type 2 CTCL cells allowing tumor growth
THIS SET IS OFTEN IN FOLDERS WITH...
Biochemical Basis of Disease: Rheumatoid Arthritis…
Biochemical Basis of Disease: Lymphocytes
Biochemical Basis of Disease: Rheumatoid Arthritis
Biochemical Basis of Disease: Current Imaging Tech…
YOU MIGHT ALSO LIKE...
all biotech drugs target/indication
Disease-modifying Antirheumatic Drugs (D…
MUSM RE Pharm
OTHER SETS BY THIS CREATOR
Math 8: Add and Subtract
Math 8: BEDMAS