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Terms in this set (14)
Name the 7 classes of drugs to tx hyperlipidemia?
1. HMG-CoA Reductase Inhibitors (Statins)
2. Fibric Acid Derivatives
3. Bile Acid Sequestrants (Resins)
5. Cholesterol Absorption Inhibitors
6. PCSK-9 Inhibitors (monoclonal antibodies)
7. CETP Inhibitors (experimental)
Name 3 Statins you would use to inhibit the "early" step in cholesterol biosynthesis invlv. HMG-CoA reductase?
(specifically, it inhibits HMG-CoA reductase)
Lovastatin (Altoprev, Mevacor)
_____ may be an adverse effect of taking statins. causing muscle pain, weakness, stiffness and elevation of creatine kinase
Name 2 Fibric Acid Derivatives you would use to tx hyperlipidemia by reducing Triglyceride levels?
Fibric acid derivatives may displace anticoagulants from albumin binding sites which would raise levels of _______.
When fibrate given w/ a ______ levels of both may incr. and cause problems w/ metabolism
Name 2 Bile Acid Sequestrants you would use to lower LDL-C, but not necessarily TG's?
Normally, 95% of ______ is reabsorbed from GI, so Chole_______ & Chole______ binding to them reduceds liver cholesterol stores
what drug would you use to raise HDL, while reducing TG and LDL?
Niacin is vitamin B3 that causes _____ synthesis and _________ breakdown of lipids
What drug would you use to inhibit cholesterol absorption @ the small intestine brush border?
Name 2 drugs you would use to inhibit Proprotein Convertase Subtilisin/Kexin type 9?
PCSK-9 in an enzyme that directs ___ receptors to degradation rather then recycling.
PCSK-9 Inhibitors ______ recycling of LDL receptors and ______clearance of ____
THIS SET IS OFTEN IN FOLDERS WITH...
PHAR 720 - SET 1
Pharm 720: Section 1 drugs
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