10 terms

Lung Pathology: Genetics of Lung Tumors

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amplification of myc + inactivation of p53 and Rb
small cell ca
gain of func mut in receptor tyrosine kinases
adenoca
what are receptor tyrosine kinases (list5)
EGFR, ROS, ALK, RET, MET
what tumor has the highest freq of TP53 mut
squam cell ca
in addition to TP53 mutations being very likely, this lung tumor also has a loss of function of ?
(talking about squam cell ca) Rb
EGFR mut commonly occurs in males/females of what descent
females, asian (this is adenoca)
EGFR mut causing adenoca is tx'd with
gefitinib(a recep tyrosine kinase inhibitor)
ALK mut tx'd with
crizotinib (a recep tyrosine kinase inhibitor) (alk mut in adenoca)
KRAS mut tx'd with which tyrosine kinase inhibitor
None (does not respond bc is downstream of EGFR AND ALK)
KRAS mut common in this population
smokers(this is adenoca)