14 terms

Pharmacology Test 2

Test 2
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Terms in this set (...)

NSAID
Motrin, Bayer, Aleve, Celebrex MOA: Prostaglandin inhibitor Used to TREAT: pain, inflammation, fever PROSTOGLANDINS: cause pain, promote inflammation, make mucous, increase temp, help platelet aggregation, BP, it is a hormone SIDE EFFECTS: May produce gastritis due to decreased mucous. Stomach bleeds may occur with prolonged use or high dosage. Increased risk of stroke and myocardial infarction, diarrhea, constipation.
Antacid
Maalox, Mylanta, Riopan MOA: Neutralizes stomach acid - not systemically absorbed INGREDIENTS: Calcium, Magnesium, Sodium Bicarbonate IMPORTANT INFO: Do not take antacids within one hour of taking other medications. SIDE EFFECTS Constipation or diarrhea, interferes with drug absorption, sodium loading
Sodium Bicarbonate
MOA: systemically absorbs SIDE EFFECTS increase of CHF
Prostoglandin Analog
MOA: suppressses secretion of gastric acid, promotes secretion of bicarbonate and cytoprotective mucous, maintains submucossal blood flow, make smucus USED TO TREAT Preention of Gastric Ulcers IMPORTANT INFO do not take if pregnant - will stimulate uterine contrations. Female pts must use birth control while taking this drug and have a ng serum preg test within 2 weeks prior to taking it. SIDE EFFECTS diarrhea, abdominal pain, spotting between periods and dysmenorrhea
H2 antagonis (H2RAs)
Tagament, Pepcid, Axid, Zantac MOA: suppress secretion of gastric acid (Decreases HCL, pepsin and gastrin) block H2 USED TO TREAT gastric & duodenal ulcers IMPORTANT INFO if they take over the coutner it is a sub pharmacuetical dose, generid ends with ine SIDE EFFECTS elderly-depression, confusion, pneuomonia
Proton Pump Inhibitors (PPI)
Nexium, Prevacid, Pilosec, Dexilant, Protonix, Aciphex MOA: decreases HCL, pepsin and gastrin, it inhibits proton pump USED TO TREAT: gastric and duodenal ulcers, GERD, prevention of ulcers SIDE EFFECTS nausea, promotes osteoporosis, rebound acid
Cytoprotective Agents
carafate, Sulcrate MOA: neutralizes stomach acid, protects stomach lining by creating a barrier, coats the stomach and its ulcers USED TO TREAT duodenal ulcers IMPORTANT INFO administer 2 hours apart from most other drugs and at least 30 minutes apart from antacids SIDE EFFECTS constipation, vertigo, flatulence
List antibiotics that are used when tx peptic ulcers
amoxil, pepto, biaxin, flagyl, achromycin v, tidamax PURPOSE: eradicate H pylori
List antisecretory agents that are used when tx peptic ulcers
H2 inhibitors: tagament, pepcid, azid, zantac PURPOSE: suppress acid secretion by blocking H2 receptors on parietal cells....PPI: dexilant, nexium, prevacid, prilosec, zegerid, protonix, aciphex PURPOSE: suppress acid secretion H+, K+ ATPase enzyme that makes gastric acid
List mucosal protectant used to tx peptic ulcers
Carafate PURPOSE: forms barrier to protect from acid/pepsin
List antisecretory agent that enhances mucosal defenses when tx peptic ulcers
cytotec PUPOSE: protect against NSAID induced ulcers
List antacids used to tx peptic ulcers
aluminum hydroxide, calcium bicarbonate, magnesium hydroxide PURPOSE: react with gastric acid to form salts
List the drug that is preferred in tx NSAID-induced ulcers
PPI
List drugs that are not recommended to tx NSAID-induced ulcers.
antacids, sucralfate, histamine2 receptor blockers