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Hema 1 Unit 2.1 Hematopoiesis

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120
This is the amount of days a typical RBC lives for in the bloodstream
14-16
This is the amount of RBCs produced from a single pluripotent stem cell
American Society for Clinical Pathologists
This group organizes RBC maturation in these stages: Rubriblast, prorubricyte, rubricyte, metarubricyte, reticulocyte, erythrocyte (RPRMRE)
Basophilic normoblast (Prorubricyte)
During this stage of maturation, the n/c ratio is 4:1, the cytoplasm is a darker blue, the nucleus exhibits HALO around the nucleus, and there is some chromatin clumping. The cell is about 12-17um
Bone marrow
This is where blood cells are produced including all of the RBCs and 60-70% of WBCs (granulocytes)
College of American Pathologists
This group organizes RBC maturation in these stages: Pronormoblst, basophilic normoblast, polychromatophilic normoblast, orthchromic normolast, reticulocyte, erythrocyte (PBPORE)
Erythroblasts
These ar red blood cell precursers found in bone marrow
Erythrocyte
During this stage of maturation the nucleus is gone, the cell moves into the blood, and the cell is a salmon color and is 6-8um in size.
Erythrocyte
This is name for red blood cells
Erythropoiesis
This term means the production of red blood cells
Erythropoietin (EPO)
This is a hormone produced in the kidneys that controls RBC production.
Hematopoeisis
This is the production, differentiation, and maturation of red blood cells.
Lymphoid stem cells
This type of stem cell can become B and T lymphocytes.
Maturation
During this process, the cytoplasm fades in color (blue to pink), cell size decreases, and the nucleus becomes smaller
Myeloid stem cell
This type of stem cell can become erythrocytes, thrombocytes, monocytes, and granulocytes.
Normoblast
This is another name for red blood cell precursors
Orthochromic normoblast (Metarubricyte)
During this stage of maturation, the n/c ratio is 1:1, the cytoplasm is a pink/orange color due to hemoglobin, the nucleus is small and puknotic, and the cell size is 8-12um
Pluripotent stem cells
This type of cell can become myeloid and lymphoid stem cells
Polychromatic normoblast (Rubricyte)
During this stage of maturation, the n/c ratio is 4:1, the cytoplasm is a grey-blue, the nucleus has a condensed and clumped chromatin witha wagon wheel appearance in the nucleus, and the cell size is 12-15um.
Pronormoblast (Rubriblast)
During this stage of maturation, the n/c ratio is 4:1, the cytoplasm is dark blue, the nucleus is a deep violet with some chromatin clumping, and the cell is about 14-19um
Red Marrow
This type of bone marrow is responsible for blood production being in almost all bones as a child and then being only in flat bones in adulthood (Flat bones)
Reticulocyte
During this stage of maturation the n/c is no longer existant, the cell is pink, it is shaped as biconcave, the nucleus is gone, and the cell size is 7-10um.
Yellow marrow
This is the result of bone marrow turning into fat cells which are not involved in blood production