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Terms in this set (208)

Interferes with production of vitamin K dependent clotting factors.

-1/2 life 42 hours (fairly long)

-INR must be monitored (given orally at the same exact time every day; almost always at 6pm unless following home regimen)

-Category X (it really heightens the risk of bleeding because it has such a narrow therapeutic index, the risks outweigh the benefits. We do not want to make pregnant women bleed out that significantly for that long. If she had complication with pregnancy she could bleed out and die.)

-Antidote: Vitamin K FFP (works on vitamin K clotting factors, sometimes that takes awhile to work. Another thing we can give in the hospital, pt. comes in car accident which is trauma and they are wearing medication bracelet that says they're on Coumadin, we need to make sure to reverse the Coumadin. We would administer orally if awake or IV cause faster. We could give FFP (fresh frozen plasma) to help the blood to clot and the INR level to go down)

-Blood tests Q. 2-3 weeks (at home need to be monitored. First once a week blood test, than 2-3, than a month but this is a life long medication, they need to be monitored that closely)

Control intake of dietary vitamin K (dark green leafy veggies like kale; if pt. generally eat lots of salad and kale they should maintain same diet so the blood test can be consistent to get correct dose, but if the patient does not eat a lot of vitamin k they shouldn't get nothing but vitamin K because then they will alter the blood tests and it will affect how the warfarin will work and make them have an increase chance for clots)

EtOH intake (vitamin K clotting factors formed in liver, if we start overloading liver with alcohol you could have issues with making the clotting factors and INR levels woul go up pretty high)

Very narrow therapeutic index, amount of drug we give patients is a fine balance. Sometimes they will take a certain dose on Mondays, smaller dose on Tuesdays and Wednesdays they will take the same dose as Monday so that we can get the patient to that therapeutic level of either INR 2-3 or INR 21/2 -3/1/2 depending on why they are taking Coumadin