13 terms

Epilepsy drugs

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Ethosuximide (MOA)
Blocks thalamic T-type Ca2+ channels
Benzodiazepines (MOA)
Increase GABA A action
Phenobarbital (MOA)
Increase GABA A action
Phenytoin
Blocks Na+ channels; zero- order kinetics
Carbamazepine (MOA)
Blocks Na+ channels
Valproic acid (MOA)
Na+ channel inactivation, and increase GABA concentration by inhibiting GABA transaminase
Gabapentin (MOA)
Primarily inhibits high-voltage- activated Ca2+ channels; designed as GABA analog
Ethosuximide (DOC)
ABSENCE
Benzodiazepines (DOC)
STATUS EPILEPTICUS
Phenobarbital (DOC)
All but ABSENCE
Carbamazepine (DOC)
Focal
Valproic acid (DOC)
All but SE
Gabapentin (DOC)
Focal