5 Written questions
5 Matching questions
- Can a baby catch malaria from mom?
- 7% of malaria cases
- Quartan malaria
- Most common in tropical regions of the developing world
- How does hemozoin screw things up? Drugs do what?
- a P. malariae
- b 72 hr recurring fevers
- c No, but sticky RBCs cause low birth weight and thus stillbirth
- d End product of plasmodium trophozoite digestion of hemoglobin. It's insoluble, not toxic to parasite. It reduces macrophage function, which aid in phagocytosing and killing merozoites, so hurts immune response. Drugs can prevent hemozoin production, and thus macrophages can kill merozoites
- e Plasmodium
5 Multiple choice questions
- 1. Duffy Blood group in west africans protects against p. vivax 2. Sickle cell trait - the heterozygous individuals. Selected for in African ancestries.
- P. vivax, invades young RBC's using a single receptor. The DUFFY BLOOD GROUPS or DUFFY ANTIGENs, makes them resistant . Fy=resistant. Fy^a or Fy^b = susceptible.
- malaria - plasmodium
- P. falciparum
5 True/False questions
John went backpacking in Asia and South America 8 years ago, and now he has malaria? How? → P. vivax can relapse after up to 8 years, fight it or treat it. Hypnozoite stage in liver is dormant stage.
Discuss P. malariae → Mild tertian malaria - 48 hr recurring fevers. Rare. Difficult to diagnose because of similarity to P. vivax. Can relapse - hypnozoite Schüffner's dots.
How many different species can cause human malaria? → P. vivax, invades young RBC's using a single receptor. The DUFFY BLOOD GROUPS or DUFFY ANTIGENs, makes them resistant . Fy=resistant. Fy^a or Fy^b = susceptible.
How does plasmodium replicate in humans → asexual schizogony
Why do Duffy antigens not help against P. falciparum? → The infected RBCs bind to epithelium causes knobs and rosettes, and ruins clearance in liver and spleen