5 Written questions
5 Matching questions
- Discuss P. malariae
- Etiological agent of Malaria
- Invades any RBC
- What is the problem with trying to treat infected individuals with malaria? Can you eradicate the disease in this way?
- Discuss P. ovale
- a Mild tertian malaria - 48 hr recurring fevers. Rare. Difficult to diagnose because of similarity to P. vivax. Can relapse - hypnozoite Schüffner's dots.
- b There will always be asymptomatic carriers
- c Quartan malaria w/ 72 hr recurring fevers. 7% of cases. ZOONOSIS only in monkeys. Invades old RBCs. Doesn't go dormant, but can exist at really small levels up to 53 years.
- d plasmodium
- e P. falciparum
5 Multiple choice questions
- P. vivax
- After the ring stage trophozoites comes out of liver and produces all the gametocytes, the mosquito bites and ingests the gametocytes from the blood. 1. Macrogamete and microgamete form zygote 2. Ookinete develops and crosses midgut epithelium 3 Ookinete to oocyst 4. Oocyst gives rise to sporozoites via sporogony and the sporozoites go to salivary gland to be injected into host.
- It can invade though at least 4 different receptors
- 1. Mosquito injects SPOROZOITE into blood 2. sporozoite invades liver cells and becomes TROPHOZOITE 3. Replication by exoerythrocytic schizogony, trophozoites to MEROZOITES 4. merozoites released and attack RBCs 5. merozoites to RING STAGE TROPHOZOITES (cycles back to merozoites or macrogametocyte) 6. Macrogametocytes and microgametocytes form zygote.
- P. vivax
5 True/False questions
Does plasmodium have antigenic variation? → Yep
Why is the immune system vital for keeping plasmodium in check? → human
How is Plasmodium different from other apicomplexans? → heteroxenous - mosquito and hman.
Intermediate host of plasmodium is → mosquito
How does hemozoin screw things up? Drugs do what? → End product of plasmodium trophozoite digestion of hemoglobin. It's insoluble, not toxic to parasite. It reduces macrophage function, which aid in phagocytosing and killing merozoites, so hurts immune response. Drugs can prevent hemozoin production, and thus macrophages can kill merozoites