5 Written questions
5 Matching questions
- Antigenic variation in plasmodium
- Life cycle of plasmodium in mosquito
- Explain why different types of plasmodium cause different types of fevers?
- Malignant Tertian Malaria
- The five species cause human malaria
- a Fevers are tied to generation of merozoites and rupture of RBC's. Rupture causes fever. Less synchrony in P. falciparum, so you have more constant fever
- b 1. Plasmodium falciparum 2. Plasmodium vivax 3. Plasmodium malariae 4. Plasmodium ovale 5. Plasmodium knowlesi
- c After the ring stage trophozoites comes out of liver and produces all the gametocytes, the mosquito bites and ingests the gametocytes from the blood. 1. Macrogamete and microgamete form zygote 2. Ookinete develops and crosses midgut epithelium 3 Ookinete to oocyst 4. Oocyst gives rise to sporozoites via sporogony and the sporozoites go to salivary gland to be injected into host.
- d 48 hr recurring fevers, More drawn out. P. falciparum
- e ~50 var genes, only one expressed at a time. var switching can lead to recrudescence.
5 Multiple choice questions
- 1. Pigment called Hemozoin 2. Apical complex lacks conoid 3. Zygotes are motile, known as ookinetes 4. Sporozoites are not enclosed in sporocysts.
- heteroxenous - mosquito and hman.
- P. falciparum
- P. vivax
- P. vivax. BTM is when you have 48 hr recurring fevers.
5 True/False questions
Most common in tropical regions of the developing world → Plasmodium
How does plasmodium replicate in mosquito? → syngamy followed by sporogony
What does P. falciparum do when it infects RBCs → The infected RBCs bind to epithelium causes knobs and rosettes, and ruins clearance in liver and spleen
Treatment of malaria - problems? → Chloroquine, Quinine, Mefloquine, Artemisinin. Drug resistance has developed for these drugs - Chloroquine sucks and Artemisinin is the best, but drug resistance to everything is a problem.
What is the problem with trying to treat infected individuals with malaria? Can you eradicate the disease in this way? → P. vivax, invades young RBC's using a single receptor. The DUFFY BLOOD GROUPS or DUFFY ANTIGENs, makes them resistant . Fy=resistant. Fy^a or Fy^b = susceptible.