5 Written questions
5 Matching questions
- Why do Duffy antigens not help against P. falciparum?
- Antigenic variation in plasmodium
- Explain why different types of plasmodium cause different types of fevers?
- 43% of malaria cases
- Definitive host of plasmodium is
- a mosquito
- b Fevers are tied to generation of merozoites and rupture of RBC's. Rupture causes fever. Less synchrony in P. falciparum, so you have more constant fever
- c ~50 var genes, only one expressed at a time. var switching can lead to recrudescence.
- d It can invade though at least 4 different receptors
- e P. vivax
5 Multiple choice questions
- children under 5 years old
- 1. Pigment called Hemozoin 2. Apical complex lacks conoid 3. Zygotes are motile, known as ookinetes 4. Sporozoites are not enclosed in sporocysts.
- End product of plasmodium trophozoite digestion of hemoglobin. It's insoluble, not toxic to parasite. It reduces macrophage function, which aid in phagocytosing and killing merozoites, so hurts immune response. Drugs can prevent hemozoin production, and thus macrophages can kill merozoites
- 1. Duffy Blood group in west africans protects against p. vivax 2. Sickle cell trait - the heterozygous individuals. Selected for in African ancestries.
- Easier to control vector in temperature regions and in developed countries there is more money and more advanced infrastructure.
5 True/False questions
Does plasmodium have antigenic variation? → Yep
The five species cause human malaria → 1. Plasmodium falciparum 2. Plasmodium vivax 3. Plasmodium malariae 4. Plasmodium ovale 5. Plasmodium knowlesi
How does plasmodium replicate in humans → syngamy followed by sporogony
7% of malaria cases → P. malariae
Hypnozoite stage is present in → Plasmodium - P. Falciparum believed to have killed Egyptian pharaohs 1500 B.C