5 Written questions
5 Matching questions
- *Clinical symptoms of plasmodium infection
- Plasmodium kills a lot of people 1-3 million per year, but most are
- Life cycle of plasmodium in vertebrate
- Invades any RBC
- Antigenic variation in plasmodium
- a 1. Mosquito injects SPOROZOITE into blood 2. sporozoite invades liver cells and becomes TROPHOZOITE 3. Replication by exoerythrocytic schizogony, trophozoites to MEROZOITES 4. merozoites released and attack RBCs 5. merozoites to RING STAGE TROPHOZOITES (cycles back to merozoites or macrogametocyte) 6. Macrogametocytes and microgametocytes form zygote.
- b ~50 var genes, only one expressed at a time. var switching can lead to recrudescence.
- c children under 5 years old
- d 1. Severe anemia 2. Cerebral malaria (coma, seizures, deadly in 25-50%) because RBC's become sticky in brain. Cytokines and NO production 3. Placental malaria (infection of the placenta, not transplacental, reduces blood flow to baby - low birth weight and still birth. 4. Can also lead to hypoglycemia and hepatosplenomegally, and pulmonary edema and kidney failure.
- e P. falciparum
5 Multiple choice questions
- malaria - plasmodium
- 1. Anemia arising from RBC destruction (merozoites released) 2. Host inflammatory response (overproduction of cytokines, fevers and chills)
- P. vivax, invades young RBC's using a single receptor. The DUFFY BLOOD GROUPS or DUFFY ANTIGENs, makes them resistant . Fy=resistant. Fy^a or Fy^b = susceptible.
- 1. Human reservoirs that are aymptomatic 2. Naïve host 3. Vector 4. Climate
5 True/False questions
Main way to eliminate malaria → Killing vector or preventing vector contact - insecticides, larvicides, bed nets
43% of malaria cases → P. vivax
7% of malaria cases → P. vivax
The five species cause human malaria → 1. Plasmodium falciparum 2. Plasmodium vivax 3. Plasmodium malariae 4. Plasmodium ovale 5. Plasmodium knowlesi
Most pathogenic strain of plasmodium → P. falciparum