5 Written questions
5 Matching questions
- Does plasmodium have antigenic variation?
- Life cycle of plasmodium in mosquito
- Main way to eliminate malaria
- This form of malaria can relapse up to 8 years
- Antigenic variation in plasmodium
- a After the ring stage trophozoites comes out of liver and produces all the gametocytes, the mosquito bites and ingests the gametocytes from the blood. 1. Macrogamete and microgamete form zygote 2. Ookinete develops and crosses midgut epithelium 3 Ookinete to oocyst 4. Oocyst gives rise to sporozoites via sporogony and the sporozoites go to salivary gland to be injected into host.
- b ~50 var genes, only one expressed at a time. var switching can lead to recrudescence.
- c Yep
- d P. vivax
- e Killing vector or preventing vector contact - insecticides, larvicides, bed nets
5 Multiple choice questions
- malaria - plasmodium
- It can invade though at least 4 different receptors
- Mosquito bite (sporozoite injection) or blood transfusion
- Quartan malaria w/ 72 hr recurring fevers. 7% of cases. ZOONOSIS only in monkeys. Invades old RBCs. Doesn't go dormant, but can exist at really small levels up to 53 years.
5 True/False questions
Can a baby catch malaria from mom? → Mosquito bite (sporozoite injection) or blood transfusion
Is plasmodium heteroxenous or monoxenous? → Yep
How is Plasmodium different from other apicomplexans? → heteroxenous - mosquito and hman.
Why is Plasmodium not as prevalent in temperate regions and developed countries? → P. vivax, invades young RBC's using a single receptor. The DUFFY BLOOD GROUPS or DUFFY ANTIGENs, makes them resistant . Fy=resistant. Fy^a or Fy^b = susceptible.
*Clinical symptoms of plasmodium infection → 1. Severe anemia 2. Cerebral malaria (coma, seizures, deadly in 25-50%) because RBC's become sticky in brain. Cytokines and NO production 3. Placental malaria (infection of the placenta, not transplacental, reduces blood flow to baby - low birth weight and still birth. 4. Can also lead to hypoglycemia and hepatosplenomegally, and pulmonary edema and kidney failure.