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Acute Fatty Liver of Pregnancy
Terms in this set (6)
Acute fatty liver in pregnancy
Is fatty infiltration of the hepatocytes of unknown etiology, along with ammonia production by the hepatocytes, leading to hypoglycemia and coagulopathy from hepatic failure.
Other conditions usually present with fatty liver
Hypertension, edema, and protienuria.
Symptoms of fatty liver in pregnancy
Nausea, vomiting, epigastric pain, anorexia, and jaundice as the disease advances.
Preeclampsia, HELLP syndrome, acute viral hepatitis, HSV hepatitis, bud Charee syndrome, systemic lupus erythematosus, hyperemesis gravidarum, thrombotic thrombocytopenia, reye's syndrome, intrahepatic cholestasis or hemorrhage, hemolytic uremic syndrome, and acetaminophen overdose.
Diagnosis of AFLP
Clinical and laboratory evidence of renal impairment, reduced hepatic metabolic activity, and coagulopathy diagnose AFLP. Many women with preeclampsia have a AFLP, but women with preeclampsia who do not have a AFLP are not usually Jaundiced, nor do they develop hypoglycemia or reduced hepatic metabolic activity.
Management of a FLP
1. Immediate obstetric consultation is indicated with AFLP. The goal is early recognition and delivery.
2. Anticipatory guidance: supportive intensive care, vaginal delivery, correction of coagulopathy, Cesarean section
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