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VCMT - 200 - Genpath Review Questions
Terms in this set (93)
1. Name two diseases caused by spirochetes
Syphilis, Lyme disease
2. Name two diseases caused by mycobacteria
3. What type of necrosis is associated with tuberculosis?
4. What kind of hypersensitivity is associated with tuberculosis?
Type 4; cell-mediated
5. What is the smallest pathogenic microorganism?
6. What is the name of the herpes virus that causes chicken pox? Where does it lay dorminant in the body?
Varicilla zoster virus
7. What infectious disease is caused by Epstein-Barr virus?
8. Which herpes virus is most likely to cause congenital defects?
9. What disease is caused by picornavirus?
10. What is the most common STI caused by a bacteria?
11. A chancre is associated by infection by which organism?
12. Name two types of bacteria that can cause toxic shock syndrome
Staph aureus, Strep pyogenes
13. Name a type of staph infection that may be particularly difficult to treat
14. Scarlet fever is caused by which bacteria?
15. Which bacteria causes otitis media?
Pneumoccus (streptococcus pneumonia)
16. Which bacterial infection is associated with pseudomembranous inflammation?
Diptheria (Cornyebacterium Diptheria)
17. Infection by which organism is associated with buboes?
Yersinia pestis (plague)
18. Name two vector-borne diseases.
Plague, lyme disease
19. Which bacteria is responsible for interfering with transmission at the NMJ?
20. Name the bacteria that may cause symptoms of a "bull's-eye" rash.
21. Which type of shock is associated with a type I hypersensitivity disorder?
Hypotonic shock (septic or anaphylaxis)
22. Which type of shock might be associated with cholera?
23. Which type of shock might be associated with myocardial infarction?
24. Which is the most common nosocomial microorganism?
26. Cilia is considered which line of defense?
First line of defense
27. Name one factor that contributes to Virchow's triad.
Endothelial cell injury, hemodynamic changes, hypercoagulability of blood
28. Which type of thrombi might mimic endocarditis?
29. Which type of thrombi might cover an aneurysm?
30. Which type of thrombi are typical of DIC?
31. What type of emboli are associated with metastasis?
Solid particle emboli
32. What kind of edema might a person suffering from chronic alcoholism develop?
Oncotic edema (d/t liver damage)
33. What kind of edema might a malnourished person have?
34. What type of hyperemia is caused by ischemic compressions?
35. What kind of hemorrhage would be caused by a diet low in citrus fruit?
Capillary hemorrhaging (scurvy)
36. Marfan's syndrome is caused by a defect in a gene that codes for which protein?
Fibrillin; structural protein
37. Xanthomas are associated with which genetic disorder?
38. Which genetic disorder is characterized by viscous exocrine secretions?
39. Which sex-linked disorder is characterized by severe muscle wasting in utero?
40. Which genetic disorder is characterized by a monosomy of sex chromosomes?
41. Benign tumours of germ cells are called:
42. Kaposi's sarcoma is caused by infection by which organism?
Herpes virus 8
43. Which hereditary cancer is characterized by numerous subcutaneous neural sheath tumours?
44. Name the primary lymphoid organs.
Thymus, bone marrow
45. T cells that do not express TCR-CD3 are called:
Natural killer cells
46. Which immune cells are responsible for killing virus-infected or tumour cells?
Natural killer cells
47. Which immune cells will differentiate into plasma cells when stimulated by an antigen?
48. Which antibody is found in milk?
49. Which immune cells can function as antigen-presenting cells?
Dendritic cells, B cells, Macrophages
50. Which type of hypersensitivity reactions are mediated by Ag-Ab immune complexes?
51. Name an infectious disease that presents with the mildest form of inflammation?
Herpes simplex (serous inflammation)
1. What does "neoplasia" mean?,
2. A benign tumour of striated muscle cell is called:,
3. Do cancer cells show contact inhibition?,
4. Neurofibromatosis is due to the inherited absence of which genetic structure?,
Tumor suppressor genes
5. Name a physical carcinogen.,
Radiation, xrays, ultraviolet light
6. Would a grade I tumour likely be benign or malignant?,
7. Name two categories of cells that may secrete alphafeto-protein.,
Normal fetal liver cells and tumor liver cells.
8. Is a glioma benign or malignant?,
Malignant tumor of glial celss
9. Metastasis can occur through blood, lymph and:,
10. What is anaplasia?,
To acquire new characteristics
11. Do benign tumours show expansive or invasive growth?,
12. Any fibrillar protein that forms a beta-pleated sheet is called:,
13. If a person becomes infected with the HIV virus, when are they likely to produce antibodies?,
Phase of acute illness (phase/group 1). Usually 3-6weeks after exposure.
14. A person with an HIV infection may have a higher incidence of which two types of tumours?,
Kaposi's sarcoma and lymphomas
15. What is an opportunistic infection?,
Infection by a pathogen that usually does not cause disease in a healthy host
16. A person with SLE who has hemolytic anemia would be characterized as having which type of hypersensitivity disorder?,
Hemolytic anemia is Type 2 hypersensitivity
17. A woman is Rh- and her mate is Rh+. What blood type must her firstborn child have to put her second born child at risk?,
18. Transplantation of a pig-valve into a human heart is called:,
19. What do post-streptococcal glomerulonephritis, polyarteritis nodosa and SLE have in common?,
All are Type 3 hypersensitivities
20. How do Grave's disease and myasthenia gravis differ?,
Grave's causes hyperthyroidism. MG causes paralysis
21. Do you have a Type I hypersensitivity? Which one?,
Hayfever. Peanut allergy.
22. Which antibody functions as an opsonin?
23. Name a human cell that doesn't contain a nucleus.,
Red blood cell
24. What is the function of cilia?,
Move substances across the cell surface
25. Kaposi's sarcoma is caused by what type of infection?,
Herpe's virus 8
26. What cells does the EBV attack?,
27. According to tumor grading, which would have the worst prognosis?,
28. Which condition is associated with 'café au lait' spots?,
29. Which Viral carcinogens are DNA viruses?,
HPV, Hepatitis B, Epstein barr virus
30. What is a Major Histocompatibility Complex? What cell would you find it on?,
Cell surface molecule. Used for presenting antigen for recognition. Found on Antigen Presenting Cells (macrophage, dendritic cell, b cells)
31. What kind of inflammation is found in Diptheria?,
32. What kind of inflammation is found in Tuberculosis? What type of necrosis would be found? What type of hypersensitivity would this be considered?,
Granulomatous inflammation. Caseous necrosis. Hypersensitivity type 4.
33. What is the first cell to appear in Inflammation?,
34. What SMI is released by mast cells? What Ig attaches to the Mast cells in an, Allergic Reaction?
35. Which cells are considered APC's?,.
Macrophages. Dendritic cells. B cells
36. What are the normal genes that protect against newly acquired oncogenes?,
tumor suppressor cells.
37. Where do B-cells mature?,
38. What is a benign tumor derived from germ cells? What type of tissue can be found in these tumors?,
Teratoma. Any tissue.
39. What are the four ways that proto-oncogenes can become oncogenes?,
Point mutation. Chromosomal rearrangement. Viral activation. Gene Amplification
40. Which cancer has the highest incidence in
41. Give an example of an endogenous carcinogen and an exogenous carcinogen Oncogene.,
42. Which human DNA viruses have been linked to cancer?,
HPV, Hepatitis B, EBV
43. What is the main difference between natural and acquired immunity?
Born with vs. needing exposure
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