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basophilic due to charge (versus peptides = acidophilic), ex: FSH, LH, TSH, same alpha but different beta?
pituitary gland / hypophysis
master gland, made by neuroectoderm + Rathke's Pouch (from roof of mouth) -> Ant + Post Lobes, fenestrated capps
pars distalis (ant lobe) + pars tuberalis (basophilic) + pars intermedia (poorly basophilic cysts formed by remnants of Rathke's pouch and filled w/ colloid
cords of cells
in parathyroid, densly packed cuboidal cells made of chief + oxyphil cells and surrounded by retic loose CT
hypothalamus blood supply
sup hypophys a -> pars tuberalis + infundibulum, forms primary capp plexus in median eminence, inf hypophys a -> pos lobe + some ant
hypophyseal portal system
primary capp plexus in median eminence --hypophys portal vv -> secondary plexus in pars distalis
hypothal lesion -> don't produce vasopressin -> renal failure -> polyuria/dehydration
tongue evagination (endoderm epith of pharnyx) -> thryoglossal duct --> add ultimobranchial bodies -> parafollicular cells/C- thyrocytes, completed in 12 weeks w/ colloid (thyrogolubin) in lumen
thyroglobulin / colloid
glycporot, contains 140 tyrosyl residues which are iodinated -> lysosomed by T-thyrocytes into T1, T2, T3, T4
parafollicular cells, larger thryocyte that contains calcitonin, never make contact w/ follic lumen
4 small glands of entwined cuboidal cords, extrathryoid glands, much more dense than the lobular thyroid gland
promotes Ca2+ release from bone, stim Ca2+ resorb by tubular kidney cells, inhib PO4- resorb by kidney, stim 1,25-dihydroxycalciferol
polyhedral cells in cords w/ retic CT + rich bl supply, cortex stim aldosterone + corticosteroid + androgen, medulla stim epi/norepi
derived from coelomic mesoderm, 3 zones: Glomerulosa (salt), Fasiculata (stress), Reticularis (sex)
derived from neural crest cells, 80% epi (20% NE), clumps of SNS ganglia w/ chromaffin granules, people w/ either A type personalties or tumors have a large medulla
zone of adrenal cortex = "Salt" secretes aldosterone/mineralocorticoids (affect by angiotensin II + and renin - ), dense round/arched cords, SER rich
adrenal cortex zone = "Stress", most of cortex, secretes corticosteroids (affect by ACTH + CRF), straight cords of SER rich cells w/ fatty droplets
adrenal cortex zone = "Sex", secretes androgens (affect by ACTH + CRF), irreg anastamosed cords of SER rich cells w/ fatty droplets + lipofuscin bodies
fetal suprarenal glands that are so strong that could result in mother androgenic
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