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Adult-health 1, Exam 3: Cushing's
Terms in this set (14)
Cushing's Dz & Cushing's Syndrome are characterized:
By hyper secretion of Cortosiol, caused by either internal or external stimuli.
Cushing's syndrome =
OUTSIDE CAUSE (glucocorticoid tx)
Cushing's dz =
INSIDE CAUSE (such as the Pituitary producing too much ACTH)
High levels of cortisol . .
reduce lymphocyte activity which creates immunosuppression.
Endogenous causes (excess production of cortisol) of Cushings's Dz:
1. Adrenal hyperplasia.
2. Adenocortical neoplasm
3. Pituitary neoplasm that secretes (ACTH)
4. Carcinomas of the lung, GI tract, or pancreas (tumors that can secrete ACTH).
Cushing's dz resulting from carcinomas usually occurs in . . .
women 25 - 40 y/o
Exogenous causes (cortisol tx of another disorder) of Cushings's Syndrome include:
The therapeutic use of glucocorticoids for Chronic fibrosis, Allergies, Cancer chemotherapy, Organ transplantation, Autoimmune Disorders, and Asthma
S&S of Cushing's Dz/Syndrome:
1. Evidence of decreased immune function & decreased inflammatory response
2. HTN (Na & water retention)
3. Changes in fat distribution, including the characteristic fat distribution (Moon face, Truncal obesity, and Buffalo hump)
Truncal obesity =
heavy trunk, thin extremities,
S&S of Cushing's Dz/Syndrome continued . .
1. Emotional lability.
2. Fractures (osteoporosis)
3. Impaired glucose tolerance
5. Muscle wasting
6. Slow healing
How is cushing's dx?
Dexamethasone suppression test.
Describe the Dexamethasone suppression test:
1. 24 hr urine collections reveal suppression of cortisol excretion in pts without Cushing's.
2. Nonsuppresion of cortisol excretion is indicative of Cushing's
3. Med are withheld & stress is reduced prior to & during test
Describe lab values for cushing's:
Increased serum Na and Glucose and decreased serum K and Ca levels
Glucocorticoids should be . . .
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